(Q37253971)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta} (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

insulin like growth factor 1 receptor

1 reference

GOA release 2020-03-11

insulin receptor

1 reference

GOA release 2020-03-11

amyloid-beta clearance

1 reference

GOA release 2020-03-11

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Michael J. Quon

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

8

William L Klein

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

author name string

Wei-Qin Zhao

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Pascale N Lacor

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Hui Chen

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Mary P Lambert

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Grant A Krafft

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

language of work or name

English

0 references

publication date

30 April 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

27 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

volume

284

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

issue

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

page(s)

18742-18753

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

27 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2707198/fullTextXML

inferred from PubMed Central ID database lookup

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Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation

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6 September 2017

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Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

6 September 2017

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Role of the Blood-Brain Barrier in the Pathogenesis of Alzheimers Disease

6 September 2017

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Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice

6 September 2017

1 reference

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

6 September 2017

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A century-old debate on protein aggregation and neurodegeneration enters the clinic

6 September 2017

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A specific amyloid-beta protein assembly in the brain impairs memory

6 September 2017

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The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer's disease

6 September 2017

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Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

6 September 2017

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Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation

6 September 2017

1 reference

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Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition

6 September 2017

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Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

6 September 2017

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Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

6 September 2017

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Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease

6 September 2017

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The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease

6 September 2017

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Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.

6 September 2017

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

6 September 2017

1 reference

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Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

6 September 2017

1 reference

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Protein aggregation and neurodegenerative disease

6 September 2017

1 reference

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Insulin and the insulin receptor in experimental models of learning and memory.

6 September 2017

1 reference

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Diabetes, Alzheimer's disease and apolipoprotein genotype

6 September 2017

1 reference

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Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

6 September 2017

1 reference

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Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme

6 September 2017

1 reference

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The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment

6 September 2017

1 reference

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Alzheimer's disease is a synaptic failure

6 September 2017

1 reference

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Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition

6 September 2017

1 reference

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Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

6 September 2017

1 reference

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Deciphering the genetic basis of Alzheimer's disease

6 September 2017

1 reference

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Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor

6 September 2017

2 references

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6 September 2017

12 December 2020

The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update

1 reference

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Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction.

6 September 2017

1 reference

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Clearing the brain's amyloid cobwebs

6 September 2017

1 reference

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Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

6 September 2017

1 reference

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Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Oxidative stress in Alzheimer's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

14 September 2017

1 reference

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Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Insulin-like growth factor and epidermal growth factor independence in human mammary carcinoma cells with c-erbB-2 gene amplification and progressively elevated levels of tyrosine-phosphorylated p185erbB-2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

A role of insulin-like growth factor 1 in beta amyloid-induced disinhibition of hippocampal neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

The role of A beta 42 in Alzheimer's disease

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

The presenilins and Alzheimer's disease

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Intranasal insulin improves cognition and modulates beta-amyloid in early AD.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Monoclonal antibodies that target pathological assemblies of Abeta.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Insulin-like growth factor-1 prevents Abeta[25-35]/(H2O2)- induced apoptosis in lymphocytes by reciprocal NF-kappaB activation and p53 inhibition via PI3K-dependent pathway

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Insulin effects on CSF norepinephrine and cognition in Alzheimer's disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Increased risk of type 2 diabetes in Alzheimer disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Metabolic regulation of brain Abeta by neprilysin.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Cortical abnormalities in Alzheimer's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707198

Amyloid beta oligomers induce impairment of neuronal insulin receptors

3 September 2018

1 reference

PubMed

12 December 2020

Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease

1 reference

PubMed

12 December 2020

Inhibition of insulin-degrading enzyme increases translocation of insulin to the nucleus in H35 rat hepatoma cells: evidence of a cytosolic pathway

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.011015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

release_pe2c63febrdbfhkpj2oj2jyb3u

27 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/pe2c63febrdbfhkpj2oj2jyb3u

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19406747%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

PubMed publication ID

19406747

1 reference