(Q48569616)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

Amyloid beta precursor protein

19 January 2020

main subject

1 reference

negative regulation of long-term synaptic potentiation

GOA release 2020-03-11

1 reference

Membrane metallo endopeptidase

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

7

Matthias Staufenbiel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Shu-Ming Huang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Akihiro Mouri

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Hideko Kokubo

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Takahiro Suemoto

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Makoto Higuchi

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Yukihiro Noda

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Haruyasu Yamaguchi

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Toshitaka Nabeshima

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Takaomi C Saido

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Nobuhisa Iwata

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

language of work or name

English

0 references

publication date

24 April 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

19 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

281

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

17941-17951

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

issue

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

19 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Metabolism of amyloid-beta peptide and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Alzheimer's disease is a synaptic failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Neutral endopeptidase modulation of septic shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric form

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

The amyloid-beta precursor protein: integrating structure with biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Short-term synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Synaptic plasticity and dynamic modulation of the postsynaptic membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Regulation of NMDA receptor trafficking by amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601372200

21 January 2018

Identifiers

DOI

10.1074/JBC.M601372200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference