(Q30917086)

27 June 2017

Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme (English)

1 reference

27 June 2017

0 references

1 reference

Frances Prelli

5

1 reference

ORCID Public Data File 2021

author name string

Laura Morelli

1

1 reference

27 June 2017

Ramiro Llovera

2

1 reference

27 June 2017

Silvia A Gonzalez

3

1 reference

27 June 2017

Jose L Affranchino

4

1 reference

27 June 2017

Blas Frangione

6

1 reference

27 June 2017

Jorge Ghiso

7

1 reference

27 June 2017

Eduardo M Castano

8

1 reference

27 June 2017

language of work or name

English

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publication date

14 April 2003

1 reference

Journal of Biological Chemistry

27 June 2017

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27 June 2017

278

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27 June 2017

26

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27 June 2017

23221-23226

1 reference

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

27 June 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Clearing the brain's amyloid cobwebs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

An unusual active site identified in a family of zinc metalloendopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Insulin-degrading enzyme: embarking on amyloid destruction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Soluble amyloid beta-protein in the cerebrospinal fluid from patients with Alzheimer's disease, vascular dementia and controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Analysis of the subsite specificity of rat insulysin using fluorogenic peptide substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

A mathematical model of the kinetics of beta-amyloid fibril growth from the denatured state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Expression of a normal and variant Alzheimer's beta-protein gene in amyloid of hereditary cerebral hemorrhage, Dutch type: DNA and protein diagnostic assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Probing the origins of increased activity of the E22Q "Dutch" mutant Alzheimer's beta-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Pathogenic effects of D23N Iowa mutant amyloid beta -protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Charge alterations of E22 enhance the pathogenic properties of the amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Degradation of amylin by insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

Functional human insulin-degrading enzyme can be expressed in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300276200

21 January 2018

Identifiers

DOI

10.1074/JBC.M300276200

1 reference

27 June 2017

1 reference