(Q38831400)

6 September 2017

title

TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro (English)

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6 September 2017

11

Dieter Häussinger

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6 September 2017

10

Ertan Mayatepek

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6 September 2017

Maria Reich

1

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6 September 2017

Kathleen Deutschmann

2

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6 September 2017

Annika Sommerfeld

3

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6 September 2017

Caroline Klindt

4

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6 September 2017

Stefanie Kluge

5

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6 September 2017

Ralf Kubitz

6

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6 September 2017

Christoph Ullmer

7

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6 September 2017

Wolfram T Knoefel

8

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6 September 2017

Diran Herebian

9

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6 September 2017

Verena Keitel

12

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6 September 2017

language of work or name

English

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publication date

29 September 2015

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6 September 2017

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6 September 2017

volume

65

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6 September 2017

issue

3

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6 September 2017

page(s)

487-501

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Endocrine functions of bile acids

6 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Endocrine and paracrine role of bile acids

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The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

21 January 2018

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Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism

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Bile acid signaling in metabolic disease and drug therapy

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Role of bile acids and bile acid receptors in metabolic regulation

21 January 2018

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TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

21 January 2018

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Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.

21 January 2018

1 reference

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Perspective: TGR5 (Gpbar-1) in liver physiology and disease

21 January 2018

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Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

21 January 2018

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TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading

21 January 2018

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Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.

21 January 2018

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Demonstration of a direct stimulatory effect of bile salts on rat colonic epithelial cell proliferation

21 January 2018

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Role of bile acids in liver injury and regeneration following acetaminophen overdose

21 January 2018

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Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice.

21 January 2018

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Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis

21 January 2018

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Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Bile salt-induced apoptosis involves NADPH oxidase isoform activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Hydrophobic bile salts trigger ceramide formation through endosomal acidification

21 January 2018

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A G protein-coupled receptor responsive to bile acids

21 January 2018

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Identification of a nuclear receptor for bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Identification of membrane-type receptor for bile acids (M-BAR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Bile acids: natural ligands for an orphan nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

21 January 2018

TGR5 in cholangiocytes

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

TGR5: pathogenetic role and/or therapeutic target in fibrosing cholangitis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Expression and function of the bile acid receptor TGR5 in Kupffer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Systemic bile acid sensing by G protein-coupled bile acid receptor 1 (GPBAR1) promotes PYY and GLP-1 release

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Mitogenic signaling pathways induced by G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Cellular functions regulated by phosphorylation of EGFR on Tyr845.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

The Src family kinases: distinct functions of c-Src, Yes, and Fyn in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Expression of growth factor receptors and targeting of EGFR in cholangiocarcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Regulation of biliary proliferation by neuroendocrine factors: implications for the pathogenesis of cholestatic liver diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Development of the bile ducts: essentials for the clinical hepatologist

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Characterization of time-related changes after experimental bile duct ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

TWEAK induces liver progenitor cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Reactive oxygen species are required for β2 adrenergic receptor-β-arrestin interactions and signaling to ERK1/2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Agonist-stimulated reactive oxygen species formation regulates beta2-adrenergic receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Involvement of the Src family kinase yes in bile salt-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

EGF receptor activation by GPCRs: an universal pathway reveals different versions

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-309458

10.1136/GUTJNL-2015-309458

21 January 2018

Identifiers

DOI

1 reference

6 September 2017

1 reference