(Q38850691)

7 September 2017

Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes (English)

1 reference

7 September 2017

1 reference

Ahmad Sharanek

1

1 reference

7 September 2017

Audrey Burban

2

1 reference

7 September 2017

Lydie Humbert

3

1 reference

7 September 2017

Pamela Bachour-El Azzi

4

1 reference

7 September 2017

Neuza Felix-Gomes

5

1 reference

7 September 2017

Dominique Rainteau

6

1 reference

7 September 2017

Andre Guillouzo

7

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7 September 2017

20 July 2015

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7 September 2017

Toxicological Sciences

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7 September 2017

147

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7 September 2017

573-587

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7 September 2017

2

1 reference

Bile Acid sulfation: a pathway of bile acid elimination and detoxification

7 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Cyclosporine A- and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Bile acids: regulation of synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

21 January 2018

Bile acid transporters

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

The use of human hepatocytes to investigate bile acid synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Biochemical mechanisms in drug-induced liver injury: certainties and doubts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

General review on in vitro hepatocyte models and their applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Phase 1 and phase 2 drug metabolism and bile acid production of HepaRG cells in a bioartificial liver in absence of dimethyl sulfoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Enterohepatic bile salt transporters in normal physiology and liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Drug-induced hepatotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Lithocholic acid as a biomarker of intrahepatic cholestasis of pregnancy during ursodeoxycholic acid treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Predominance of human versus rat phenotype in the metabolic pathways for bile acid synthesis by hybrid WIF-B9 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Enterohepatic transport of bile salts and genetics of cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Cytochromes p450: roles in diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Determination of the hepatocellularity number for human, dog, rabbit, rat and mouse livers from protein concentration measurements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

The bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Bile salt transporters: molecular characterization, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

New molecular insights into the mechanisms of cholestasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV155

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFV155

1 reference

7 September 2017

1 reference