(Q34736335)

4 August 2017

title

Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures (English)

1 reference

4 August 2017

Ewa Ellis

6

0 references

author name string

Jie Liu

1

1 reference

4 August 2017

Hong Lu

2

1 reference

4 August 2017

Yuan-Fu Lu

3

1 reference

4 August 2017

Xiaohong Lei

4

1 reference

4 August 2017

Julia Yue Cui

5

1 reference

4 August 2017

Stephen C Strom

7

1 reference

4 August 2017

Curtis D Klaassen

8

1 reference

4 August 2017

language of work or name

1 reference

23 July 2014

1 reference

4 August 2017

published in

Toxicological Sciences

1 reference

4 August 2017

volume

141

1 reference

4 August 2017

issue

2

1 reference

4 August 2017

page(s)

538-546

1 reference

Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

4 August 2017

cites work

1 reference

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Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

7 July 2018

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Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice

7 July 2018

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Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis

7 July 2018

1 reference

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The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

7 July 2018

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Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice

7 July 2018

1 reference

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Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice

7 July 2018

1 reference

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The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease

7 July 2018

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A novel bile acid-activated vitamin D receptor signaling in human hepatocytes

7 July 2018

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Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

7 July 2018

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7 July 2018

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Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes

7 July 2018

1 reference

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Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression

7 July 2018

1 reference

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Fifty years of advances in bile acid synthesis and metabolism

7 July 2018

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7 July 2018

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Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport

7 July 2018

1 reference

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OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes?

7 July 2018

1 reference

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Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells

7 July 2018

1 reference

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Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

7 July 2018

1 reference

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OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia

7 July 2018

1 reference

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

7 July 2018

1 reference

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Regulation of hepatic transporters by xenobiotic receptors

7 July 2018

1 reference

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Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.

7 July 2018

1 reference

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Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4271050

Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4271050

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4271050

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4271050

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

7 July 2018

1 reference

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Bile acids: natural ligands for an orphan nuclear receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4271050

Identification of a nuclear receptor for bile acids

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4271050

Regulation of bile acid biosynthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4271050

Effects of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocytes in primary culture

7 July 2018

1 reference

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Expression and regulation of the sterol half-transporter genes ABCG5 and ABCG8 in rats

7 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU151

Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU151

The use of human hepatocytes to investigate bile acid synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU151

Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU151

Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU151

Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU151

Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU151

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU151

Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU151

Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU151

Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25055961

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25055961

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/TOXSCI/KFU151

1 reference

4 August 2017

1 reference

4 August 2017

1 reference