(Q38866592)

7 September 2017

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch (English)

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7 September 2017

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9

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7 September 2017

Wendy R Gordon

1

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author name string

Brandon Zimmerman

2

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7 September 2017

Li He

3

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7 September 2017

Laura J Miles

4

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7 September 2017

Jiuhong Huang

5

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7 September 2017

Kittichoat Tiyanont

6

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7 September 2017

Debbie G McArthur

7

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7 September 2017

Jon C Aster

8

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7 September 2017

Joseph J Loparo

10

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7 September 2017

Stephen C Blacklow

11

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7 September 2017

language of work or name

English

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publication date

4 June 2015

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7 September 2017

8

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inferred from page(s)

published in

Developmental Cell

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7 September 2017

33

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7 September 2017

6

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7 September 2017

729-736

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describes a project that uses

7 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4481192/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Molecular tension sensors report forces generated by single integrin molecules in living cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Defining single molecular forces required to activate integrin and notch signaling

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Notch ligand endocytosis: mechanistic basis of signaling activity

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Restriction of receptor movement alters cellular response: physical force sensing by EphA2.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

The canonical Notch signaling pathway: unfolding the activation mechanism

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Stretching single talin rod molecules activates vinculin binding

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Structural basis for autoinhibition of Notch

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Single myosin molecule mechanics: piconewton forces and nanometre steps

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481192

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

22 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26051539

12 December 2020

inferred from PubMed ID database lookup

Visualizing DNA replication at the single-molecule level

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26051539

12 December 2020

inferred from PubMed ID database lookup

Visualizing mechanical tension across membrane receptors with a fluorescent sensor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26051539

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.DEVCEL.2015.05.004

1 reference

7 September 2017

1 reference

7 September 2017

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