(Q38867604)

7 September 2017

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer (English)

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7 September 2017

9

Zora Modrusan

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7 September 2017

Jeffrey Eastham-Anderson

7

object named as

Jeffrey Eastham Anderson

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7 September 2017

Felipe de Sousa e Melo

1

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7 September 2017

Antonina V Kurtova

2

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7 September 2017

Jonathan M Harnoss

3

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7 September 2017

Noelyn Kljavin

4

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7 September 2017

Joerg D Hoeck

5

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7 September 2017

Jeffrey Hung

6

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7 September 2017

Elaine E Storm

8

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7 September 2017

Hartmut Koeppen

10

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7 September 2017

Gerrit J P Dijkgraaf

11

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7 September 2017

Robert Piskol

12

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7 September 2017

Frederic J de Sauvage

13

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7 September 2017

language of work or name

English

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publication date

1 March 2017

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7 September 2017

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7 September 2017

543

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7 September 2017

7647

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7 September 2017

676-680

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https://scigraph.springernature.com/pub.10.1038/nature21713

7 September 2017

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cites work

Colorectal cancer statistics, 2014.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

A genetic model for colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Identification and expansion of human colon-cancer-initiating cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Crypt stem cells as the cells-of-origin of intestinal cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

The developing cancer stem-cell model: clinical challenges and opportunities

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Prospective identification of tumorigenic breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Identification of human brain tumour initiating cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

A restricted cell population propagates glioblastoma growth after chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Lymph node-independent liver metastasis in a model of metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Sequential cancer mutations in cultured human intestinal stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

The cancer stem cell gamble.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Targeting metastasis-initiating cells through the fatty acid receptor CD36

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

The intraportal injection model: a practical animal model for hepatic metastases and tumor cell dissemination in human colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Fast and SNP-tolerant detection of complex variants and splicing in short reads

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

voom: Precision weights unlock linear model analysis tools for RNA-seq read counts

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

limma powers differential expression analyses for RNA-sequencing and microarray studies

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

The Sequence Alignment/Map format and SAMtools

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Integrative genomics viewer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Quantitative set analysis for gene expression: a method to quantify gene set differential expression including gene-gene correlations

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Molecular signatures database (MSigDB) 3.0.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21713

7 January 2021

Identifiers

DOI

10.1038/NATURE21713

1 reference

Dimensions Publication ID

7 September 2017

0 references

1 reference