(Q42615205)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

title

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Alan R. Clarke

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Owen J Sansom

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Toby J Phesse

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Dimitris Athineos

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Richard Kemp

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Margaret Frame

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

12

Hans Clevers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

5

Rachel A Ridgway

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

9

Vanesa Muncan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

7

Julie A Wilkins

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

14

Douglas J Winton

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

3

Kevin Myant

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1

Gabrielle H Ashton

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Victoria Marsh Durban

6

object named as

Victoria Marsh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

13

Valerie Brunton

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

author name string

Kristi Neufeld

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Xiaoyan Wang

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Rosalie C Sears

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

language of work or name

English

0 references

publication date

1 August 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

number of pages

11

1 reference

inferred from page(s)

published in

Developmental Cell

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

page(s)

259-269

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

Mutant p53 drives invasion by promoting integrin recycling

10 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Crypt stem cells as the cells-of-origin of intestinal cancer

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Distinct thresholds govern Myc's biological output in vivo

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

27 May 2018

The intestinal stem cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Bmi1 is expressed in vivo in intestinal stem cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Identification of stem cells in small intestine and colon by marker gene Lgr5

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Myc deletion rescues Apc deficiency in the small intestine

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

N-MYC regulates focal adhesion kinase expression in human neuroblastoma.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Distinct Wnt signaling pathways have opposing roles in appendage regeneration

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Conditional deletion of beta-catenin reveals its role in liver growth and regeneration

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Integrin-regulated FAK-Src signaling in normal and cancer cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

FAK regulates biological processes important for the pathogenesis of cancer

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Focal adhesion kinase: the first ten years

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Protection against mucosal injury by growth factors and cytokines

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Stem cells: the intestinal stem cell as a paradigm.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Generalized lacZ expression with the ROSA26 Cre reporter strain

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

The relationship between ionizing radiation-induced apoptosis and stem cells in the small and large intestine

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Stem cells in gastrointestinal epithelium: numbers, characteristics and death

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Control of adhesion-dependent cell survival by focal adhesion kinase

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Radiation-hypersensitive cells in small intestinal crypts; their relationships to clonogenic cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Inhibition of intestinal polyposis with reduced angiogenesis in ApcMin/+ mice due to decreases in c-Myc expression.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Expression pattern of Wnt signaling components in the adult intestine.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Evidence for active Wnt signaling during postresection intestinal adaptation.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Apc deficiency predisposes to renal carcinoma in the mouse

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291717

Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20708588

12 December 2020

inferred from PubMed ID database lookup

Methods for the isolation of intact epithelium from the mouse intestine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20708588

12 December 2020

inferred from PubMed ID database lookup

FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20708588

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.DEVCEL.2010.07.015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20708588%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference