(Q38876540)

English

Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications

scientific article published on January 2016

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scholarly article

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Europe PubMed Central

7 September 2017

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Europe PubMed Central

Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications (English)

1 reference

Europe PubMed Central

7 September 2017

pulmonary hypertension

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Stephen L Archer

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Europe PubMed Central

7 September 2017

language of work or name

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publication date

1 January 2016

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Europe PubMed Central

7 September 2017

Advances in Experimental Medicine and Biology

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Europe PubMed Central

7 September 2017

903

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Europe PubMed Central

7 September 2017

29-53

1 reference

Europe PubMed Central

7 September 2017

Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children

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21 January 2018

Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension

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21 January 2018

Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

1 reference

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21 January 2018

A redox-based O2 sensor in rat pulmonary vasculature.

1 reference

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21 January 2018

Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.

1 reference

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21 January 2018

Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes

1 reference

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21 January 2018

Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies

1 reference

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21 January 2018

Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells

1 reference

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21 January 2018

An essential role for DNA methyltransferase DNMT3B in cancer cell survival

1 reference

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21 January 2018

Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia

1 reference

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21 January 2018

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

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21 January 2018

An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

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21 January 2018

The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted

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21 January 2018

Oxidative stress in severe pulmonary hypertension

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21 January 2018

SOD2: a new type of tumor-suppressor gene?

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21 January 2018

Dysregulation of HSG triggers vascular proliferative disorders

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21 January 2018

An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension

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21 January 2018

Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease

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21 January 2018

Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells

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21 January 2018

Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene

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21 January 2018

Inflammation in pulmonary arterial hypertension.

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21 January 2018

Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension?

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21 January 2018

The superoxide dismutase mimetic, tempol, blunts right ventricular hypertrophy in chronic hypoxic rats.

1 reference

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21 January 2018

The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase

1 reference

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21 January 2018

The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

1 reference

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21 January 2018

Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy.

1 reference

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21 January 2018

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

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21 January 2018

A dosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension.

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21 January 2018

Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway

1 reference

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21 January 2018

Increased plasma serotonin in primary pulmonary hypertension

1 reference

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21 January 2018

Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells

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21 January 2018

Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis

1 reference

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21 January 2018

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

1 reference

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21 January 2018

Integrated molecular profiling of SOD2 expression in multiple myeloma

1 reference

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21 January 2018

Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines

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21 January 2018

Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension

1 reference

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21 January 2018

Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide

1 reference

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21 January 2018

Mitochondrial redox state regulates transcription of the nuclear-encoded mitochondrial protein manganese superoxide dismutase: a proposed adaptive response to mitochondrial redox imbalance.

1 reference

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21 January 2018

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

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21 January 2018

Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

1 reference

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21 January 2018

High pulsatility flow induces adhesion molecule and cytokine mRNA expression in distal pulmonary artery endothelial cells.

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21 January 2018

Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype

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21 January 2018

Erlotinib, an effective epidermal growth factor receptor tyrosine kinase inhibitor, induces p27KIP1 up-regulation and nuclear translocation in association with cell growth inhibition and G1/S phase arrest in human non-small-cell lung cancer cell lin

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21 January 2018

Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

1 reference

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21 January 2018

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

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21 January 2018

Small molecule glucokinase activators as novel anti-diabetic agents.

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21 January 2018

Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer

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21 January 2018

Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension

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21 January 2018

Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis

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21 January 2018

Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension

1 reference

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21 January 2018

Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension

1 reference

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21 January 2018

Diversity in mitochondrial function explains differences in vascular oxygen sensing.

1 reference

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21 January 2018

Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels

1 reference

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21 January 2018

O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor

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21 January 2018

Metabolic modulation of glioblastoma with dichloroacetate

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21 January 2018

Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

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21 January 2018

Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.

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21 January 2018

Genetic basis of pulmonary arterial hypertension: current understanding and future directions

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21 January 2018

CpG methylation represses the activity of the rat prolactin promoter in rat GH3 pituitary cell lines

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21 January 2018

Prognostic factors for survival in human immunodeficiency virus-associated pulmonary arterial hypertension

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21 January 2018

Increased [18F]fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol

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21 January 2018

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

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21 January 2018

Cytochrome c activates K+ channels before inducing apoptosis

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21 January 2018

In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats

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21 January 2018

Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas.

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Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension

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Activation of K+ channels: an essential pathway in programmed cell death

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21 January 2018

Inhaled nitric oxide in primary pulmonary hypertension: a safe and effective agent for predicting response to nifedipine

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21 January 2018

The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension

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21 January 2018

Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease

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21 January 2018

Reversal of experimental pulmonary hypertension by PDGF inhibition

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

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21 January 2018

Updated clinical classification of pulmonary hypertension.

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21 January 2018

Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension.

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21 January 2018

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

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21 January 2018

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

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21 January 2018

Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension

1 reference

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21 January 2018

Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene

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21 January 2018

Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?

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21 January 2018

Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis

1 reference

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21 January 2018

Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family

1 reference

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21 January 2018

Erlotinib monotherapy for stage IIIB/IV non-small cell lung cancer: a multicenter trial by the Korean Cancer Study Group.

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21 January 2018

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

1 reference

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21 January 2018

Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1.

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21 January 2018

Acute oxygen-sensing mechanisms

1 reference

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21 January 2018

Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle

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21 January 2018

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

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21 January 2018

Hydrogen peroxide elicits activation of bovine pulmonary arterial soluble guanylate cyclase by a mechanism associated with its metabolism by catalase.

1 reference

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21 January 2018

Alterations of cellular bioenergetics in pulmonary artery endothelial cells

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21 January 2018

BMP signaling controls PASMC KV channel expression in vitro and in vivo

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21 January 2018

PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression

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21 January 2018

Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia

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21 January 2018

Mutation of the protein kinase A phosphorylation site influences the anti-proliferative activity of mitofusin 2.

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21 January 2018

Mitochondrial dynamics--mitochondrial fission and fusion in human diseases

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21 January 2018

Transgenic Mice Overexpressing the 5-Hydroxytryptamine Transporter Gene in Smooth Muscle Develop Pulmonary Hypertension

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21 January 2018

Identifiers

10.1007/978-1-4899-7678-9_3

1 reference

Europe PubMed Central

7 September 2017

1 reference

Europe PubMed Central

7 September 2017

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