(Q38887917)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25868794%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25868794%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

author name string

Ping Zhang

1

1 reference

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5 March 2020

Levi C M Buil

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25868794%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Gang Li

5

1 reference

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5 March 2020

Olaf van Tellingen

6

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5 March 2020

language of work or name

English

0 references

publication date

24 April 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25868794%20AND%20SRC:MED&resulttype=core&format=json

International Journal of Cancer

5 March 2020

published in

1 reference

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5 March 2020

volume

137

1 reference

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5 March 2020

issue

8

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5 March 2020

page(s)

2007-2018

1 reference

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The Polycomb complex PRC2 and its mark in life

5 March 2020

cites work

1 reference

Epigenetic gene regulation in stem cells and correlation to cancer

21 January 2018

1 reference

Deregulation of H3K27 methylation in cancer

21 January 2018

1 reference

The role of EZH2 in tumour progression

21 January 2018

1 reference

Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells.

21 January 2018

1 reference

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

21 January 2018

1 reference

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

1 reference

The blood-brain barrier and cancer: transporters, treatment, and Trojan horses

21 January 2018

1 reference

Blood-brain barrier and chemotherapeutic treatment of brain tumors

21 January 2018

1 reference

Chemotherapy delivery issues in central nervous system malignancy: a reality check.

21 January 2018

1 reference

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

1 reference

Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA.

21 January 2018

1 reference

Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP.

21 January 2018

1 reference

Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux

21 January 2018

1 reference

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan

21 January 2018

1 reference

Co-administration strategy to enhance brain accumulation of vandetanib by modulating P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp1/Abcg2) mediated efflux with m-TOR inhibitors.

21 January 2018

1 reference

ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy

21 January 2018

1 reference

Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration.

21 January 2018

1 reference

ABC transporters as phenotypic markers and functional regulators of stem cells

21 January 2018

1 reference

Molecular pharmacology of ABCG2 and its role in chemoresistance

21 January 2018

1 reference

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

21 January 2018

1 reference

Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma

21 January 2018

1 reference

Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth

21 January 2018

1 reference

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1

21 January 2018

1 reference

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.

21 January 2018

1 reference

Dual mTORC1 and mTORC2 inhibitor Palomid 529 penetrates the blood-brain barrier without restriction by ABCB1 and ABCG2.

21 January 2018

1 reference

PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel

21 January 2018

1 reference

Role of P-glycoprotein and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941.

21 January 2018

1 reference

Several major antiepileptic drugs are substrates for human P-glycoprotein

21 January 2018

1 reference

Targeting core (mutated) pathways of high-grade gliomas: challenges of intrinsic resistance and drug efflux.

21 January 2018

1 reference

Substrate-dependent breast cancer resistance protein (Bcrp1/Abcg2)-mediated interactions: consideration of multiple binding sites in in vitro assay design

21 January 2018

1 reference

P-glycoprotein, CYP3A, and plasma carboxylesterase determine brain and blood disposition of the mTOR Inhibitor everolimus (Afinitor) in mice.

21 January 2018

1 reference

Insight into the cooperation of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) at the blood-brain barrier: a case study examining sorafenib efflux clearance

21 January 2018

1 reference

Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-GLYCOprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar

21 January 2018

1 reference

Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on the brain distribution of a novel BRAF inhibitor: vemurafenib (PLX4032)

21 January 2018

1 reference

P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib

21 January 2018

1 reference

Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone

21 January 2018

1 reference

Quantitative proteomics of transporter expression in brain capillary endothelial cells isolated from P-glycoprotein (P-gp), breast cancer resistance protein (Bcrp), and P-gp/Bcrp knockout mice

21 January 2018

1 reference

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

21 January 2018

1 reference

Modulation of oral bioavailability of anticancer drugs: from mouse to man.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IJC.29566

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25868794%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference