(Q34096178)

31 July 2017

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title

Modulation of oral bioavailability of anticancer drugs: from mouse to man. (English)

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31 July 2017

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Schellens JH

1

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31 July 2017

Malingré MM

2

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31 July 2017

Kruijtzer CM

3

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31 July 2017

Bardelmeijer HA

4

1 reference

31 July 2017

van Tellingen O

5

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31 July 2017

Schinkel AH

6

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31 July 2017

Beijnen JH

7

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31 July 2017

language of work or name

English

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publication date

1 December 2000

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European Journal of Pharmaceutical Sciences

31 July 2017

published in

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31 July 2017

volume

12

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31 July 2017

issue

2

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31 July 2017

page(s)

103-110

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Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression.

31 July 2017

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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7 January 2021

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

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7 January 2021

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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7 January 2021

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

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7 January 2021

Oral chemotherapy: rationale and future directions

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7 January 2021

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities

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7 January 2021

The bioavailability of oral GI147211 (GG211), a new topoisomerase I inhibitor

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7 January 2021

Topoisomerase I inhibitors: the relevance of prolonged exposure for present clinical development

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7 January 2021

Biochemistry of multidrug resistance mediated by the multidrug transporter

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7 January 2021

Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins

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7 January 2021

In vitro techniques for studying drug metabolism

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7 January 2021

Bioavailability of low-dose oral etoposide

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7 January 2021

ABC Transporters: From Microorganisms to Man

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7 January 2021

Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients

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7 January 2021

Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer. The European Cancer Centre

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7 January 2021

Phase I and pharmacologic study of the combination paclitaxel and carboplatin as first-line chemotherapy in stage III and IV ovarian cancer

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7 January 2021

A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver

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7 January 2021

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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7 January 2021

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

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7 January 2021

Fetus-specific expression of a form of cytochrome P-450 in human livers

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7 January 2021

Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice.

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7 January 2021

Inhibition and induction of cytochrome P450 and the clinical implications

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7 January 2021

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

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7 January 2021

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

1 reference

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7 January 2021

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

1 reference

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7 January 2021

Co-administration of cyclosporin enables oral therapy with paclitaxel

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7 January 2021

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

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7 January 2021

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

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7 January 2021

Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor

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7 January 2021

The physiological function of drug-transporting P-glycoproteins

1 reference

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7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900153-6

7 January 2021

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900153-6

7 January 2021

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900153-6

7 January 2021

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900153-6

7 January 2021

Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900153-6

7 January 2021

Genetic polymorphisms in xenobiotic metabolism.

1 reference

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7 January 2021

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

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7 January 2021

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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7 January 2021

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice

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7 January 2021

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

1 reference

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7 January 2021

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

1 reference

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7 January 2021

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900153-6

7 January 2021

The barrier function of CYP3A4 and P-glycoprotein in the small bowel

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7 January 2021

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

1 reference

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7 January 2021

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900153-6

7 January 2021

Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone

1 reference

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7 January 2021

Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1).

1 reference

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7 January 2021

Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900153-6

7 January 2021

10.1016/S0928-0987(00)00153-6

Identifiers

DOI

1 reference

31 July 2017

1 reference