(Q38908764)

7 September 2017

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited (English)

1 reference

7 September 2017

0 references

1 reference

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Tim J Kendall

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

David H Wilson

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Stephen J. Wigmore

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Stuart J Forbes

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

author name string

Luke Boulter

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Rachel V Guest

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Davina Wojtacha

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Andrew J Robson

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Rachel A Ridgway

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Kay Samuel

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Nico Van Rooijen

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Simon T Barry

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

language of work or name

English

0 references

publication date

17 February 2015

1 reference

7 September 2017

17

1 reference

Journal of Clinical Investigation

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

125

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

1269-1285

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

3 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4362247/fullTextXML

inferred from PubMed Central ID database lookup

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1 reference

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9 September 2017

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Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation

9 September 2017

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9 September 2017

1 reference

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Stress-induced cleavage of Myc promotes cancer cell survival

9 September 2017

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Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer

9 September 2017

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Activated macrophages promote Wnt/β-catenin signaling in cholangiocarcinoma cells

9 September 2017

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The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

9 September 2017

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Nek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1.

9 September 2017

1 reference

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Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.

9 September 2017

1 reference

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M2 macrophages activate WNT signaling pathway in epithelial cells: relevance in ulcerative colitis

9 September 2017

1 reference

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Crystal Structures of Lgr4 and Its Complex with R-Spondin1

9 September 2017

1 reference

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β-catenin at the centrosome: discrete pools of β-catenin communicate during mitosis and may co-ordinate centrosome functions and cell cycle progression

9 September 2017

1 reference

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Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer

9 September 2017

1 reference

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Porcn-dependent Wnt signaling is not required prior to mouse gastrulation

9 September 2017

1 reference

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Structural basis for R-spondin recognition by LGR4/5/6 receptors

9 September 2017

1 reference

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Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours

9 September 2017

1 reference

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Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia

9 September 2017

1 reference

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Macrophage biology in development, homeostasis and disease

9 September 2017

1 reference

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The development of highly potent inhibitors for porcupine

9 September 2017

1 reference

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Transforming growth factor β neutralization ameliorates pre-existing hepatic fibrosis and reduces cholangiocarcinoma in thioacetamide-treated rats

9 September 2017

1 reference

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Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

9 September 2017

1 reference

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Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling

9 September 2017

1 reference

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R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

9 September 2017

1 reference

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A lineage of myeloid cells independent of Myb and hematopoietic stem cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

9 September 2017

1 reference

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Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome

9 September 2017

1 reference

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

9 September 2017

1 reference

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Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion

9 September 2017

1 reference

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Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation

9 September 2017

1 reference

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Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

9 September 2017

1 reference

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Macrophage Wnt7b is critical for kidney repair and regeneration

9 September 2017

1 reference

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Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

9 September 2017

1 reference

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Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Crypt stem cells as the cells-of-origin of intestinal cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Investigating Wnt signaling: a chemogenomic safari

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Changing international trends in mortality rates for liver, biliary and pancreatic tumours

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Establishment and characterisation of six human biliary tract cancer cell lines

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

A new nuclear component of the Wnt signalling pathway

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Porcupine-mediated lipidation is required for Wnt recognition by Wls.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Animal PET for thioacetamide-induced rat cholangiocarcinoma: a novel and reliable platform

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Histogenesis of cholangiomas and cholangiocarcinomas in thioacetamide fed rats

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Two new human cholangiocarcinoma cell lines and their cytogenetics and responses to growth factors, hormones, cytokines or immunologic effector cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Inhibition of Wnt signaling induces cell apoptosis and suppresses cell proliferation in cholangiocarcinoma cells

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

cDNA microarray proﬁling of rat cholangiocarcinoma induced by thioacetamide

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Circulating CD14(+) CD16(+) monocyte levels predict tissue invasive character of cholangiocarcinoma.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Immunohistochemical and mutational analyses of Wnt signaling components and target genes in intrahepatic cholangiocarcinomas.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Stromal expression of MMP-9 and urokinase receptor is inversely associated with liver metastasis and with infiltrating growth in human colorectal cancer: a novel approach from immune/inflammatory aspect.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Changing pattern of epidemiology in intrahepatic cholangiocarcinoma

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362247

Kupffer cell depletion by liposome-delivered drugs: comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid

4 November 2018

1 reference

12 December 2020

Expression of urokinase-type plasminogen activator receptor in hepatocellular carcinoma

1 reference

12 December 2020

Exome sequencing of liver fluke-associated cholangiocarcinoma

1 reference

12 December 2020

Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI76452

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25689248%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference