(Q38910336)

7 September 2017

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title

Disciplined approach to drug discovery and early development (English)

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7 September 2017

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Robert M Plenge

1

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7 September 2017

language of work or name

English

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publication date

1 July 2016

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Science Translational Medicine

7 September 2017

published in

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7 September 2017

volume

8

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7 September 2017

issue

349

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7 September 2017

page(s)

349ps15

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Diagnosing the decline in pharmaceutical R&D efficiency

7 September 2017

cites work

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

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21 January 2018

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An analysis of the attrition of drug candidates from four major pharmaceutical companies

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When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

21 January 2018

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The support of human genetic evidence for approved drug indications

21 January 2018

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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

21 January 2018

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A decade of innovation in pharmaceutical R&D: the Chorus model.

21 January 2018

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Validating therapeutic targets through human genetics

21 January 2018

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Biological insights from 108 schizophrenia-associated genetic loci

21 January 2018

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Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders.

21 January 2018

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Health and population effects of rare gene knockouts in adult humans with related parents

21 January 2018

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A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins

21 January 2018

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The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members

21 January 2018

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Hypocretin (orexin) deficiency in human narcolepsy.

21 January 2018

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The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication

21 January 2018

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The link between the GBA gene and parkinsonism

21 January 2018

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Selective small-molecule inhibition of an RNA structural element

21 January 2018

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Data gaps limit the translational potential of preclinical research

21 January 2018

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Cystic fibrosis in an era of genomically guided therapy

21 January 2018

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Digital medical tools and sensors

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I-SPY 2: an adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy

21 January 2018

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21 January 2018

Identifiers

DOI

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7 September 2017

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