(Q38910336)

7 September 2017

1 reference

title

Disciplined approach to drug discovery and early development (English)

1 reference

7 September 2017

1 reference

Robert M Plenge

1

1 reference

PubMed ID

27464747

7 September 2017

language of work or name

English

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publication date

1 July 2016

1 reference

Science Translational Medicine

7 September 2017

1 reference

7 September 2017

8

1 reference

7 September 2017

349

1 reference

7 September 2017

349ps15

1 reference

Diagnosing the decline in pharmaceutical R&D efficiency

7 September 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Innovation in the pharmaceutical industry: New estimates of R&D costs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

How to improve R&D productivity: the pharmaceutical industry's grand challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Can the pharmaceutical industry reduce attrition rates?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

An analysis of the attrition of drug candidates from four major pharmaceutical companies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Clinical development success rates for investigational drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

The support of human genetic evidence for approved drug indications

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

A decade of innovation in pharmaceutical R&D: the Chorus model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Validating therapeutic targets through human genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Biological insights from 108 schizophrenia-associated genetic loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Health and population effects of rare gene knockouts in adult humans with related parents

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Hypocretin (orexin) deficiency in human narcolepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

The link between the GBA gene and parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Selective small-molecule inhibition of an RNA structural element

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Data gaps limit the translational potential of preclinical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Cystic fibrosis in an era of genomically guided therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

Digital medical tools and sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

I-SPY 2: an adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF2608

10.1126/SCITRANSLMED.AAF2608

21 January 2018

Identifiers

DOI

1 reference

7 September 2017

1 reference

PubMed ID

27464747