(Q31035567)

28 June 2017

title

Data gaps limit the translational potential of preclinical research (English)

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28 June 2017

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1

Robin J Kleiman

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28 June 2017

Michael D Ehlers

2

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28 June 2017

language of work or name

English

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publication date

1 January 2016

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Science Translational Medicine

28 June 2017

published in

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28 June 2017

volume

8

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28 June 2017

issue

320

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28 June 2017

page(s)

320ps1

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Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept

28 June 2017

cites work

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Believe it or not: how much can we rely on published data on potential drug targets?

21 January 2018

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Drug development: Raise standards for preclinical cancer research

21 January 2018

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Second act: Drug repurposing gets a boost as academic researchers join the search for novel uses of existing drugs

21 January 2018

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Drug repurposing: far beyond new targets for old drugs.

21 January 2018

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Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks

21 January 2018

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Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases

21 January 2018

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Mining for therapeutic gold

21 January 2018

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The future is much closer collaboration between the pharmaceutical industry and academic medical centers

21 January 2018

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Drug repositioning for Alzheimer's disease.

21 January 2018

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A century of cholesterol and coronaries: from plaques to genes to statins

21 January 2018

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Statins in neurological disorders: an overview and update.

21 January 2018

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Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice: protection by atorvastatin and pitavastatin

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAC9888

Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance

21 January 2018

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Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits.

21 January 2018

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Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice.

21 January 2018

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Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome

21 January 2018

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A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome

21 January 2018

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A role for metabolism in Rett syndrome pathogenesis: New clinical findings and potential treatment targets

21 January 2018

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Statins and epilepsy: preclinical studies, clinical trials and statin-anticonvulsant drug interactions

21 January 2018

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Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates.

21 January 2018

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Stroke: a step closer to statin therapy for stroke?

21 January 2018

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Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels.

21 January 2018

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Statins in traumatic brain injury

21 January 2018

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Statins and neuroprotection: a prescription to move the field forward

21 January 2018

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Statins and neuroprotection: basic pharmacology needed

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAC9888

10.1126/SCITRANSLMED.AAC9888

21 January 2018

Identifiers

DOI

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28 June 2017

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