(Q34481465)

2 August 2017

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title

An analysis of the attrition of drug candidates from four major pharmaceutical companies (English)

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2 August 2017

3

Andrew R Leach

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Michael J Waring

1

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John Arrowsmith

2

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Paul D Leeson

4

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Sam Mandrell

5

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Robert M Owen

6

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Garry Pairaudeau

7

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William D Pennie

8

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Stephen D Pickett

9

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Jibo Wang

10

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Owen Wallace

11

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Alex Weir

12

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publication date

19 June 2015

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Nature Reviews Drug Discovery

2 August 2017

published in

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volume

14

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issue

7

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page(s)

475-486

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Clinical development success rates for investigational drugs

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cites work

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Getting pharmaceutical R&D back on target

31 March 2020

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Can the pharmaceutical industry reduce attrition rates?

31 March 2020

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

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The influence of drug-like concepts on decision-making in medicinal chemistry

31 March 2020

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Generation of a set of simple, interpretable ADMET rules of thumb

31 March 2020

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Physiochemical drug properties associated with in vivo toxicological outcomes

31 March 2020

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Pharmacological promiscuity: dependence on compound properties and target specificity in a set of recent Roche compounds

31 March 2020

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Probing the links between in vitro potency, ADMET and physicochemical parameters.

31 March 2020

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Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules

31 March 2020

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Inflation of correlation in the pursuit of drug-likeness

31 March 2020

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Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

31 March 2020

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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

31 March 2020

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Relating molecular properties and in vitro assay results to in vivo drug disposition and toxicity outcomes

31 March 2020

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Improving the odds of success in drug discovery: choosing the best compounds for in vivo toxicology studies

31 March 2020

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The influence of the 'organizational factor' on compound quality in drug discovery

31 March 2020

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Escape from flatland: increasing saturation as an approach to improving clinical success

31 March 2020

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The influence of target family and functional activity on the physicochemical properties of pre-clinical compounds

31 March 2020

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Dependence of molecular properties on proteomic family for marketed oral drugs

31 March 2020

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Accurate In Silico log PPredictions: One Can't Embrace the Unembraceable

31 March 2020

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Lipophilicity in drug discovery

31 March 2020

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Reducing safety-related drug attrition: the use of in vitro pharmacological profiling.

31 March 2020

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Defining optimum lipophilicity and molecular weight ranges for drug candidates-Molecular weight dependent lower logD limits based on permeability

31 March 2020

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A quantitative assessment of hERG liability as a function of lipophilicity

31 March 2020

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Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potential

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD4609

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2 August 2017

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