(Q38911503)

7 September 2017

title

A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease (English)

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7 September 2017

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Günter K Stalla

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Marcelo Paez-pereda

object named as

Marcelo Paez-Pereda

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author name string

Mathias Riebold

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7 September 2017

Christian Kozany

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7 September 2017

Lee Freiburger

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7 September 2017

Michael Buchfelder

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7 September 2017

Felix Hausch

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7 September 2017

Günter K Stalla

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7 September 2017

language of work or name

English

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publication date

9 February 2015

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7 September 2017

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7 September 2017

volume

21

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7 September 2017

issue

3

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7 September 2017

page(s)

276-280

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https://scigraph.springernature.com/pub.10.1038/nm.3776

7 September 2017

exact match

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cites work

Corticosteroid Inhibition of ACTH Secretion*

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The molecular pathogenesis of corticotroph tumors

21 January 2018

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21 January 2018

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Management of Cushing disease

21 January 2018

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Glucocorticoid receptors and Cushing's disease

21 January 2018

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Reduced levels of hsp90 compromise steroid receptor action in vivo

21 January 2018

1 reference

The molecular chaperone Hsp90 can negatively regulate the activity of a glucocorticosteroid-dependent promoter

21 January 2018

1 reference

Disassembly of transcriptional regulatory complexes by molecular chaperones

21 January 2018

1 reference

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

21 January 2018

1 reference

Identification and initial SAR of silybin: an Hsp90 inhibitor

21 January 2018

1 reference

Targeting the dynamic HSP90 complex in cancer

21 January 2018

1 reference

Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines.

21 January 2018

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The function of steroid hormone receptors is inhibited by the hsp90-specific compound geldanamycin

21 January 2018

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Elucidation of the Hsp90 C-terminal inhibitor binding site

21 January 2018

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Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70

21 January 2018

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Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions

21 January 2018

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Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70.

21 January 2018

1 reference

Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles

21 January 2018

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Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast.

21 January 2018

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Modulation of the Hsp90 chaperone cycle by a stringent client protein

21 January 2018

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Retinoic acid prevents experimental Cushing syndrome

21 January 2018

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Mutations at positions 547-553 of rat glucocorticoid receptors reveal that hsp90 binding requires the presence, but not defined composition, of a seven-amino acid sequence at the amino terminus of the ligand binding domain

21 January 2018

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Antagonism between Nur77 and glucocorticoid receptor for control of transcription.

21 January 2018

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Identification of DNA elements cooperatively activating proopiomelanocortin gene expression in the pituitary glands of transgenic mice

21 January 2018

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Transplantation of ACTH-secreting pituitary tumor cells in athymic nude mice

21 January 2018

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Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease.

21 January 2018

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Tissue glucocorticoid resistance/hypersensitivity syndromes.

21 January 2018

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Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket

21 January 2018

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Unliganded and hormone-bound glucocorticoid receptors interact with distinct hydrophobic sites in the Hsp90 C-terminal domain

21 January 2018

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Structure of an Hsp90-Cdc37-Cdk4 complex.

21 January 2018

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The chaperone Hsp90: changing partners for demanding clients

21 January 2018

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Nucleotide binding states of hsp70 and hsp90 during sequential steps in the process of glucocorticoid receptor.hsp90 heterocomplex assembly

21 January 2018

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Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization

21 January 2018

1 reference

A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket

21 January 2018

1 reference

Multitargeted therapy of cancer by silymarin

21 January 2018

1 reference

The use of silymarin in the treatment of liver diseases

21 January 2018

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Dynamics-Based Discovery of Allosteric Inhibitors: Selection of New Ligands for the C-terminal Domain of Hsp90.

21 January 2018

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Steroid receptor interactions with heat shock protein and immunophilin chaperones

21 January 2018

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12 December 2020

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

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12 December 2020

Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation.

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12 December 2020

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells

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12 December 2020

Identifiers

DOI

10.1038/NM.3776

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7 September 2017

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