(Q38918179)

7 September 2017

Site-selective protein-modification chemistry for basic biology and drug development (English)

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7 September 2017

Filipa P da Cruz

2

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Omar Boutureira

object named as

Omar Boutureira

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3

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author name string

Nikolaus Krall

series ordinal

1

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PubMed ID

26791892

7 September 2017

Gonçalo J L Bernardes

series ordinal

4

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7 September 2017

30 November 2015

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7 September 2017

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7 September 2017

8

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7 September 2017

2

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7 September 2017

103-113

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https://scigraph.springernature.com/pub.10.1038/nchem.2393

7 September 2017

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cites work

Protein posttranslational modifications: the chemistry of proteome diversifications

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Choosing an effective protein bioconjugation strategy

21 January 2018

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Chemical modification of proteins at cysteine: opportunities in chemistry and biology.

21 January 2018

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Synthesis of proteins by native chemical ligation

21 January 2018

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A chemical toolkit for proteins--an expanded genetic code

21 January 2018

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Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins

21 January 2018

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Bioorthogonal chemistry: fishing for selectivity in a sea of functionality

21 January 2018

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Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEM.2393

More than add-on: chemoselective reactions for the synthesis of functional peptides and proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Selective chemical protein modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Generation and purification of highly specific antibodies for detecting post-translationally modified proteins in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Erythropoietin derived by chemical synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Expressed protein ligation: a general method for protein engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Chromatin as an expansive canvas for chemical biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

H3R42me2a is a histone modification with positive transcriptional effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

A pan-specific antibody for direct detection of protein histidine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Synthetic phosphorylation of p38α recapitulates protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Chemoselective Staudinger-phosphite reaction of azides for the phosphorylation of proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

The site-specific installation of methyl-lysine analogs into recombinant histones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Traceless and site-specific ubiquitination of recombinant proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Expanding the diversity of chemical protein modification allows post-translational mimicry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Influence of DOTA chelator position on biodistribution and targeting properties of (111)In-labeled synthetic anti-HER2 affibody molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Concerted, rapid, quantitative, and site-specific dual labeling of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Monitoring endocytic trafficking of anthrax lethal factor by precise and quantitative protein labeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

A pretargeted PET imaging strategy based on bioorthogonal Diels-Alder click chemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

The use of (18)F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Diels-Alder reaction for tumor pretargeting: in vivo chemistry can boost tumor radiation dose compared with directly labeled antibody.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Genetically encoded tetrazine amino acid directs rapid site-specific in vivo bioorthogonal ligation with trans-cyclooctenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Converting a solvatochromic fluorophore into a protein-based pH indicator for extreme acidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Antibody-drug conjugates: an emerging concept in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

PEG conjugates in clinical development or use as anticancer agents: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Therapeutic protein-polymer conjugates: advancing beyond PEGylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

N-terminal protein modification through a biomimetic transamination reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Optimized clinical performance of growth hormone with an expanded genetic code

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Investigation into temperature-induced aggregation of an antibody drug conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Mild method for succinimide hydrolysis on ADCs: impact on ADC potency, stability, exposure, and efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Facile conversion of cysteine and alkyl cysteines to dehydroalanine on protein surfaces: versatile and switchable access to functionalized proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

A general approach to site-specific antibody drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

A Pictet-Spengler ligation for protein chemical modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Palladium-triggered deprotection chemistry for protein activation in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Diels-Alder reaction-triggered bioorthogonal protein decaging in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Click to release: instantaneous doxorubicin elimination upon tetrazine ligation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Genetic encoding of photocaged cysteine allows photoactivation of TEV protease in live mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Photocontrol of Tyrosine Phosphorylation in Mammalian Cells via Genetic Encoding of Photocaged Tyrosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Genetic incorporation of unnatural amino acids into proteins in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post-Translational Modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Spacer length shapes drug release and therapeutic efficacy of traceless disulfide-linked ADCs targeting the tumor neovasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

Cysteine-Selective Reactions for Antibody Conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

21 January 2018

Making sense of nonsense

1 reference

12 December 2020

Immunoconjugates containing novel maytansinoids: promising anticancer drugs

1 reference

12 December 2020

Site-specific attachment of functionalized poly(ethylene glycol) to the amino terminus of proteins

1 reference

12 December 2020

Genetically encoded click chemistry for single-molecule FRET of proteins.

1 reference

12 December 2020

Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate

1 reference

12 December 2020

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation

1 reference

12 December 2020

Designer proteins: applications of genetic code expansion in cell biology

1 reference

12 December 2020

A direct method for site-specific protein acetylation

1 reference

12 December 2020

Nonenzymatic polyubiquitination of expressed proteins

1 reference

12 December 2020

Methods for converting cysteine to dehydroalanine on peptides and proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2393

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEM.2393

1 reference

PubMed ID

26791892

Dimensions Publication ID

7 September 2017

0 references

1 reference

PubMed ID

26791892