(Q38924286)

7 September 2017

1 reference

title

Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance? (English)

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7 September 2017

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2

Amira Klip

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7 September 2017

Warren L Lee

1

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7 September 2017

1 September 2016

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7 September 2017

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7 September 2017

31

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7 September 2017

5

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7 September 2017

336-345

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Pathogenesis of insulin resistance in skeletal muscle

7 September 2017

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Phenotypic heterogeneity of the endothelium: II. Representative vascular beds

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Caveolae: where incoming and outgoing messengers meet

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Vascular transport of insulin to rat cardiac muscle. Central role of the capillary endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

The endothelial cell: an "early responder" in the development of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Obesity and free fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Mechanism of nitric oxide-induced vasodilatation: refilling of intracellular stores by sarcoplasmic reticulum Ca2+ ATPase and inhibition of store-operated Ca2+ influx.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Skeletal muscle insulin resistance is the primary defect in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Processing of cell-bound insulin by capillary and macrovascular endothelial cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Effect of endothelium-specific insulin resistance on endothelial function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Reduced access to insulin-sensitive tissues in dogs with obesity secondary to increased fat intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Endothelial cells actively concentrate insulin during its transendothelial transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

How protein hormones reach their target cells. Receptor-mediated transcytosis of hCG through endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Transcapillary insulin transfer in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Processing of insulin by bovine endothelial cells in culture. Internalization without degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Obesity blunts microvascular recruitment in human forearm muscle after a mixed meal

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

The barrier within: endothelial transport of hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Lipid-induced insulin resistance does not impair insulin access to skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Muscle microvasculature's structural and functional specializations facilitate muscle metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Plasticity of endothelial cells: rapid dedifferentiation of freshly isolated high endothelial venule endothelial cells outside the lymphoid tissue microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Insulin action in muscle and adipose tissue in type 2 diabetes: The significance of blood flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I) or insulin/IGF-I hybrid receptors in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

The source of the circulating aggregate of insulin in type I diabetic patients is therapeutic insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Signaling mechanisms regulating endothelial permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Microvascular permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Rates of glucose uptake in adipose tissue and muscle in vivo after a mixed meal in women with morbid obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Insulin action and insulin resistance in vascular endothelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Development, maintenance and disruption of the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Capillary diameter and geometry in cardiac and skeletal muscle studied by means of corrosion casts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Are the precapillary sphincters and metarterioles universal components of the microcirculation? An historical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Endothelial glycocalyx dysfunction in disease: albuminuria and increased microvascular permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Mechanisms for insulin resistance: common threads and missing links

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Glucose transport in human skeletal muscle cells in culture. Stimulation by insulin and metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Nitric oxide release accounts for insulin's vascular effects in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Caveolae-deficient Endothelial Cells Show Defects in the Uptake and Transport of Albuminin Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Endothelial insulin resistance protects the heart against prolonged ischemia-reperfusion injury but does not prevent insulin transport across the endothelium in a mouse Langendorff model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Insulin transport within skeletal muscle transverse tubule networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Delayed transcapillary transport of insulin to muscle interstitial fluid in obese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Increased extravasation of macromolecules in skeletal muscles of the Zucker rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Loss of insulin-mediated microvascular perfusion in skeletal muscle is associated with the development of insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

21 January 2018

Structure of caveolae

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Lipid-induced insulin resistance is not mediated by impaired transcapillary transport of insulin and glucose in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Role of NF-kappaB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Endothelial permeability for macromolecules. Mechanistic aspects of pathophysiological modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Receptor-mediated transcytosis of follicle-stimulating hormone through the rat testicular microvasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Insulin-mediated hemodynamic changes are impaired in muscle of Zucker obese rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

The vascular endothelial cell mediates insulin transport into skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Caveolin-1 is required for vascular endothelial insulin uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Importance of transcapillary insulin transport to dynamics of insulin action after intravenous glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Insulin transport across capillaries is rate limiting for insulin action in dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Insulin sensitivity of muscle capillary recruitment in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Insulin permeability across an in vitro dynamic model of endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

Co-Regulation of Transcellular and Paracellular Leak Across Microvascular Endothelium by Dynamin and Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00010.2016

10.1152/PHYSIOL.00010.2016

21 January 2018

Identifiers

DOI

1 reference

7 September 2017

1 reference

PubMed ID

27511460