(Q38942069)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25378054%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7 (English)

1 reference

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22 February 2020

1 reference

6

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22 February 2020

author name string

Rachel H Church

1

1 reference

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22 February 2020

Arjun Krishnakumar

2

1 reference

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22 February 2020

Annika Urbanek

3

1 reference

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22 February 2020

Stefan Geschwindner

4

1 reference

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22 February 2020

Julie Meneely

5

1 reference

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22 February 2020

Barbro Basta

7

1 reference

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22 February 2020

Sean Monaghan

8

1 reference

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22 February 2020

Christopher Elliot

9

1 reference

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22 February 2020

Maria Strömstedt

10

1 reference

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22 February 2020

Neil Ferguson

11

1 reference

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22 February 2020

Finian Martin

12

1 reference

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22 February 2020

Derek P Brazil

13

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22 February 2020

language of work or name

English

0 references

publication date

1 February 2015

1 reference

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22 February 2020

1 reference

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22 February 2020

volume

466

1 reference

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22 February 2020

issue

1

1 reference

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22 February 2020

page(s)

55-68

1 reference

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Extracellular BMP-antagonist regulation in development and disease: tied up in knots

22 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

BMP and BMP inhibitors in bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Bone morphogenetic proteins in development and homeostasis of kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Consequences of knocking out BMP signaling in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Activation of bone morphogenetic protein 4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type I transforming growth factor-beta receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Bone morphogenetic protein 7: a broad-spectrum growth factor with multiple target therapeutic potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Endogenous BMP-7 is a critical molecular determinant of the reversibility of obstruction-induced renal injuries

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

The BMP-7-Smad1/5/8 pathway promotes kidney repair after obstruction induced renal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Bone morphogenetic protein-7 and connective tissue growth factor: novel targets for treatment of renal fibrosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

BMP-7 does not protect against bleomycin-induced lung or skin fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Focus on molecules: gremlin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Gremlin1 is required for skeletal development and postnatal skeletal homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Gremlin: an example of the re-emergence of developmental programmes in diabetic nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Gremlin aggravates hyperglycemia-induced podocyte injury by a TGFβ/smad dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Allelic depletion of grem1 attenuates diabetic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Co-regulation of Gremlin and Notch signalling in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Gremlin: a novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

In vivo delivery of Gremlin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by recovering bone morphogenetic protein-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Insulin receptor substrate 2 and FoxO3a signalling are involved in E-cadherin expression and transforming growth factor-β1-induced repression in kidney epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Deletion of Gremlin1 increases cell proliferation and migration responses in mouse embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Heparan sulfate proteoglycans mediate the angiogenic activity of the vascular endothelial growth factor receptor-2 agonist gremlin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Bone morphogenetic protein-inducer tilorone identified by high-throughput screening is antifibrotic in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140771

21 January 2018

Identifiers

DOI

10.1042/BJ20140771

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25378054%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference