(Q38945736)

9 January 2018

title

Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation (English)

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9 January 2018

0 references

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7

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PubMed publication ID

7 September 2017

Alexander V Chibalin

8

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Robby Z Tom

3

object named as

Robby Z Tom

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9 January 2018

author name string

Sergej Pirkmajer

1

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9 January 2018

Sameer S Kulkarni

2

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9 January 2018

Fiona A Ross

4

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9 January 2018

Simon A Hawley

5

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9 January 2018

D Grahame Hardie

6

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9 January 2018

language of work or name

English

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publication date

22 October 2014

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9 January 2018

number of pages

10

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inferred from page(s)

published in

Diabetes

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9 January 2018

volume

64

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9 January 2018

issue

2

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9 January 2018

page(s)

360-369

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9 January 2018

AMPK: a target for drugs and natural products with effects on both diabetes and cancer

cites work

1 reference

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Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes

17 June 2018

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DNA synthesis as a therapeutic target: the first 65 years

17 June 2018

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The ancient drug salicylate directly activates AMP-activated protein kinase

17 June 2018

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Effects of methotrexate on inflammatory alterations induced by obesity: an in vivo and in vitro study.

17 June 2018

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

17 June 2018

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Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo

17 June 2018

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Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis

17 June 2018

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Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

17 June 2018

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Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

17 June 2018

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Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study

17 June 2018

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AMPK and PPARdelta agonists are exercise mimetics

17 June 2018

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5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.

17 June 2018

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Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP

17 June 2018

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Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.

17 June 2018

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AMP-activated protein kinase signaling in metabolic regulation

17 June 2018

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Diagnosing AICA-ribosiduria by capillary electrophoresis

17 June 2018

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Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis

17 June 2018

1 reference

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The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle

17 June 2018

1 reference

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AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC

17 June 2018

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Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle

17 June 2018

1 reference

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5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice

17 June 2018

1 reference

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Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells

17 June 2018

1 reference

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Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase

17 June 2018

1 reference

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The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

Impaired glucose handling in active rheumatoid arthritis: relationship to peripheral insulin resistance.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

Polyglutamation of methotrexate. Is methotrexate a prodrug?

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

AICA-riboside: safety, tolerance, and pharmacokinetics of a novel adenosine-regulating agent

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

Effects of methotrexate and of environmental factors on glycolysis and metabolic energy state in cultured Ehrlich ascites carcinoma cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

AMPK is a direct adenylate charge-regulated protein kinase.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

A1 adenosine receptor partial agonist lowers plasma FFA and improves insulin resistance induced by high-fat diet in rodents

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

Mapping of the bovine genes of the de novo AMP synthesis pathway

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

A1 adenosine receptor antagonism improves glucose tolerance in Zucker rats.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5703413

Metabolism of 5-amino-4-imidazolecarboxamide riboside in cardiac and skeletal muscle. Effects on purine nucleotide synthesis

21 August 2018

1 reference

12 December 2020

Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle

1 reference

12 December 2020

Purine de novo synthesis as the basis of synergism of methotrexate and 6-mercaptopurine in human malignant lymphoblasts of different lineages

1 reference

12 December 2020

Glucose tolerance, insulin sensitivity and β-cell function in patients with rheumatoid arthritis treated with or without low-to-medium dose glucocorticoids

1 reference

12 December 2020

Aminoimidazolecarboxamide excretion in vitamin-B12 and folic-acid deficiencies

1 reference

12 December 2020

S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB14-0508

1 reference

9 January 2018

PMC publication ID

5703413

1 reference

9 January 2018

PubMed publication ID

25338814

1 reference

9 January 2018