(Q38947387)

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Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.

scientific article published on 15 October 2014

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scholarly article

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21 February 2020

Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells (English)

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21 February 2020

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Myriam Chaumeil

4

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21 February 2020

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Ilwoo Park

1

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21 February 2020

Joydeep Mukherjee

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21 February 2020

Motokazu Ito

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21 February 2020

Llewellyn E Jalbert

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21 February 2020

Karin Gaensler

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21 February 2020

Sabrina M Ronen

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21 February 2020

Sarah J Nelson

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21 February 2020

Russell O Pieper

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21 February 2020

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15 October 2014

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21 February 2020

Cancer Research

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21 February 2020

74

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21 February 2020

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21 February 2020

7115-7124

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21 February 2020

describes a project that uses

magnetic resonance imaging

1 reference

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inferred from title

Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma

1 reference

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Early Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damage

1 reference

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9 September 2017

Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma

1 reference

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Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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9 September 2017

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253720

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Tumour M2-pyruvate kinase: a gastrointestinal cancer marker

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The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents

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On the Origin of Cancer Cells

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Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR

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Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine

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Analysis of volume MRI and MR spectroscopic imaging data for the evaluation of patients with brain tumors

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9 September 2017

Temozolomide and treatment of malignant glioma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253720

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9 September 2017

Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging

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Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence

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Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide

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inferred from PubMed ID database lookup

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10.1158/0008-5472.CAN-14-0849

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Europe PubMed Central

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21 February 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320009%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320009%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

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