(Q83350735)

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A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16

scientific article published on 15 May 2006

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Europe PubMed Central

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21 January 2020

A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16 (English)

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Europe PubMed Central

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21 January 2020

author name string

Billottet C

1

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21 January 2020

Grandage VL

2

1 reference

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21 January 2020

Gale RE

3

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21 January 2020

Quattropani A

4

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21 January 2020

Rommel C

5

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21 January 2020

Vanhaesebroeck B

6

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21 January 2020

Khwaja A

7

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21 January 2020

publication date

15 May 2006

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21 January 2020

1 reference

Europe PubMed Central

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21 January 2020

25

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21 January 2020

50

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21 January 2020

6648-6659

1 reference

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21 January 2020

Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders

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Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

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Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells

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Regulation of Akt/PKB Ser473 phosphorylation

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Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

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7 January 2021

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Assessment of somatic mutations in phosphatidylinositol 3-kinase gene in human lymphoma and acute leukaemia

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7 January 2021

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Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F

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7 January 2021

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Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

1 reference

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7 January 2021

based on heuristic

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The phosphoinositide 3-kinase pathway

1 reference

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7 January 2021

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p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

1 reference

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7 January 2021

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Phosphatase and tensin homologue phosphorylation in the C-terminal regulatory domain is frequently observed in acute myeloid leukaemia and associated with poor clinical outcome

1 reference

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7 January 2021

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A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

1 reference

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7 January 2021

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Constitutive phosphoinositide 3-kinase activation in acute myeloid leukemia is not due to p110delta mutations

1 reference

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7 January 2021

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

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7 January 2021

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Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

1 reference

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7 January 2021

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PI3K/Akt signalling pathway and cancer.

1 reference

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7 January 2021

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Towards an understanding of isoform specificity in phosphoinositide 3-kinase signalling in lymphocytes

1 reference

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7 January 2021

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PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

1 reference

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7 January 2021

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Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells

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7 January 2021

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Etoposide: four decades of development of a topoisomerase II inhibitor

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7 January 2021

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Specific Requirement for the p85-p110α Phosphatidylinositol 3-Kinase during Epidermal Growth Factor-stimulated Actin Nucleation in Breast Cancer Cells

1 reference

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7 January 2021

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PI 3-kinase p110beta: a new target for antithrombotic therapy

1 reference

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7 January 2021

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Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

1 reference

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7 January 2021

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Clinical significance of cellular drug resistance in childhood leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209670

7 January 2021

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Genetics of myeloid leukemias

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7 January 2021

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Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

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7 January 2021

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Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: direct evidence of PI3K activation

1 reference

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7 January 2021

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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7 January 2021

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Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia

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7 January 2021

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

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7 January 2021

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Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

1 reference

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7 January 2021

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Mutations in the receptor tyrosine kinase pathway are associated with clinical outcome in patients with acute myeloblastic leukemia harboring t(8;21)(q22;q22).

1 reference

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7 January 2021

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The protein kinase B/Akt signalling pathway in human malignancy

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphoinositide 3-kinase in T cell activation and survival.

1 reference

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7 January 2021

based on heuristic

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PI3K in lymphocyte development, differentiation and activation

1 reference

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7 January 2021

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Human cancer, PTEN and the PI-3 kinase pathway

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Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing

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The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors

1 reference

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Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

1 reference

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based on heuristic

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Oncogenic mutations of PIK3CA in human cancers

1 reference

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7 January 2021

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High frequency of mutations of the PIK3CA gene in human cancers

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PIK3CA is implicated as an oncogene in ovarian cancer.

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PTEN: life as a tumor suppressor

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The role of FLT3 in haematopoietic malignancies

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Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

1 reference

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7 January 2021

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Phosphoinositide 3-kinases: a conserved family of signal transducers

1 reference

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7 January 2021

based on heuristic

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Signaling by distinct classes of phosphoinositide 3-kinases

1 reference

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7 January 2021

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p110δ, a novel phosphoinositide 3-kinase in leukocytes

1 reference

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7 January 2021

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Phosphorylation of the PTEN tail regulates protein stability and function

1 reference

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7 January 2021

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

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7 January 2021

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Nuclear labelling of leukaemic blast cells with tritiated thymidine triphosphate after daunomycin

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Variable product purity and functional capacity after CD34 selection: a direct comparison of the CliniMACS (v2.1) and Isolex 300i (v2.5) clinical scale devices

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7 January 2021

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Activation of the PI3K/Akt pathway and chemotherapeutic resistance

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7 January 2021

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Phosphoinositide 3-kinase signalling--which way to target?

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7 January 2021

based on heuristic

inferred from DOI database lookup

Survival of acute myeloid leukemia cells requires PI3 kinase activation

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7 January 2021

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Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias

1 reference

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