(Q38950360)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

single cell transcriptomics

28 February 2020

main subject

1 reference

A curated database reveals trends in single-cell transcriptomics

https://www.nxn.se/single-cell-studies/data.tsv

7 February 2021

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Michael DiDonato

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

31

Bryan Laffitte

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

8

Austin Swafford

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

18

Carolina N Turk

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

author name string

Brandon Taylor

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Qihui Jin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Van Nguyen-Tran

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Shelly Meeusen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

You-Qing Zhang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Anwesh Kamireddy

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Andrew F Powers

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

John Walker

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

John Lamb

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Badry Bursalaya

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

George Harb

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Minhua Qiu

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Christophe M Filippi

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Lisa Deaton

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Wilma L Suarez-Pinzon

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Yahu Liu

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Xueshi Hao

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Tingting Mo

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Shanshan Yan

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Jing Li

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Ann E Herman

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Bernhard J Hering

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Tom Wu

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

H Martin Seidel

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Peter McNamara

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Richard Glynne

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

language of work or name

English

0 references

publication date

26 October 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

external data available at URL

28 February 2020

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE68625

1 reference

A curated database reveals trends in single-cell transcriptomics

https://www.nxn.se/single-cell-studies/data.tsv

7 February 2021

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

page(s)

8372

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

28 February 2020

copyright license

start time

26 October 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms9372

0 references

cites work

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Betatrophin versus bitter-trophin and the elephant in the room: time for a new normal in β-cell regeneration research

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

RETRACTED: Betatrophin: a hormone that controls pancreatic β cell proliferation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human β-cell replication: a revised model of human β-cell G1/S control

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Early-onset, coexisting autoimmunity and decreased HLA-mediated susceptibility are the characteristics of diabetes in Down syndrome.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

In vitro proliferation of adult human beta-cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Activation, regulation, and inhibition of DYRK1A.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Relationship between beta-cell mass and diabetes onset.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Regulation of DNA double-strand break repair pathway choice

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

NFAT signaling and the invention of vertebrates

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

GSK3 inhibitors: development and therapeutic potential

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Risk for posttransplant Diabetes mellitus with current immunosuppressive medications

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Small-molecule inducer of β cell proliferation identified by high-throughput screening.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Segregation of myoblast fusion and muscle-specific gene expression by distinct ligand-dependent inactivation of GSK-3β.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Inhibition of GSK3 promotes replication and survival of pancreatic beta cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Correction of hyperglycemia in diabetic mice transplanted with reversibly immortalized pancreatic beta cells controlled by the tet-on regulatory system

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Recovery from diabetes in mice by beta cell regeneration

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Control of pancreatic β cell regeneration by glucose metabolism.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Proliferation of sorted human and rat beta cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Growth and regeneration of adult beta cells does not involve specialized progenitors.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Increased prevalence of Down's syndrome in individuals with type 1 diabetes in Denmark: A nationwide population-based study.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639830

Evaluation of beta-cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21cip

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26496802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26496802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Type 2 diabetes: pathogenesis and treatment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26496802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS9372

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

28 February 2020

ADS bibcode

2015NatCo...6.8372S

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496802%20AND%20SRC:MED&resulttype=core&format=json