(Q35790372)

10 August 2017

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title

GSK3 inhibitors: development and therapeutic potential (English)

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10 August 2017

Philip Cohen

1

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PubMed ID

15173837

10 August 2017

Michel Goedert

series ordinal

2

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10 August 2017

1 June 2004

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Nature Reviews Drug Discovery

10 August 2017

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10 August 2017

3

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10 August 2017

479-487

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10 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrd1415

10 August 2017

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cites work

The Hormonal Control of Glycogen Metabolism in Mammalian Muscle by Multivalent Phosphorylation

1 reference

Glycogen Synthase Kinase-3 from Rabbit Skeletal Muscle

31 March 2020

1 reference

Phosphorylation and regulation of beta-catenin by casein kinase I epsilon

31 March 2020

1 reference

Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization

31 March 2020

1 reference

Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event

31 March 2020

1 reference

The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

31 March 2020

1 reference

31 March 2020

The renaissance of GSK3

1 reference

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

31 March 2020

1 reference

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

31 March 2020

1 reference

GSK3, a master switch regulating cell-fate specification and tumorigenesis

31 March 2020

1 reference

Biochemical interactions in the wnt pathway

31 March 2020

1 reference

Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice

31 March 2020

1 reference

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes

31 March 2020

1 reference

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

31 March 2020

1 reference

A molecular mechanism for the effect of lithium on development

31 March 2020

1 reference

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

31 March 2020

1 reference

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

31 March 2020

1 reference

Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression

31 March 2020

1 reference

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

31 March 2020

1 reference

GSK-3-selective inhibitors derived from Tyrian purple indirubins

31 March 2020

1 reference

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases

31 March 2020

1 reference

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

31 March 2020

1 reference

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

31 March 2020

1 reference

The specificities of protein kinase inhibitors: an update

31 March 2020

1 reference

Molecular targets of lithium action

31 March 2020

1 reference

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta

31 March 2020

1 reference

Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching

31 March 2020

1 reference

Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats

31 March 2020

1 reference

Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo

31 March 2020

1 reference

Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418

31 March 2020

1 reference

Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors

31 March 2020

1 reference

Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

31 March 2020

1 reference

Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase.

31 March 2020

1 reference

Neurodegenerative tauopathies

31 March 2020

1 reference

A cell biological perspective on Alzheimer's disease

31 March 2020

1 reference

Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100.

31 March 2020

1 reference

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

31 March 2020

1 reference

Divergent roles of GSK3 and CDK5 in APP processing

31 March 2020

1 reference

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

31 March 2020

1 reference

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

31 March 2020

1 reference

A familial Alzheimer's disease locus on chromosome 1.

31 March 2020

1 reference

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

31 March 2020

1 reference

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

31 March 2020

1 reference

In Vitro Phosphorylation of the Cytoplasmic Domain of the Amyloid Precursor Protein by Glycogen Synthase Kinase-3β

31 March 2020

1 reference

APP processing is regulated by cytoplasmic phosphorylation

31 March 2020

1 reference

Tau is a candidate gene for chromosome 17 frontotemporal dementia

31 March 2020

1 reference

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

31 March 2020

1 reference

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

31 March 2020

1 reference

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.

31 March 2020

1 reference

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

31 March 2020

1 reference

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

31 March 2020

1 reference

Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells

31 March 2020

1 reference

Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments

31 March 2020

1 reference

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

31 March 2020

1 reference

Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.

31 March 2020

1 reference

Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.

31 March 2020

1 reference

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

31 March 2020

1 reference

Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.

31 March 2020

1 reference

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

31 March 2020

1 reference

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

31 March 2020

1 reference

Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.

31 March 2020

1 reference

FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain

31 March 2020

1 reference

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

31 March 2020

1 reference

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

31 March 2020

1 reference

Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease

31 March 2020

1 reference

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

31 March 2020

1 reference

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

31 March 2020

1 reference

Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation

31 March 2020

1 reference

Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3.

31 March 2020

1 reference

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

31 March 2020

1 reference

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

31 March 2020

1 reference

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors

31 March 2020

1 reference

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

31 March 2020

1 reference

A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun

31 March 2020

1 reference

Cancer morbidity in psychiatric patients: influence of lithium carbonate treatment.

31 March 2020

1 reference

Role of AMP-activated protein kinase in mechanism of metformin action

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1415

1 reference

10 August 2017

1 reference

PubMed ID

15173837