(Q44754701)

English

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases

scientific article published in February 2004

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 December 2017

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

Emmanuel Mikros

5

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Europe PubMed Central

PubMed publication ID

6 December 2017

Andrea Musacchio

7

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Europe PubMed Central

PubMed publication ID

6 December 2017

9

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Europe PubMed Central

PubMed publication ID

6 December 2017

Vassilios Myrianthopoulos

object named as

Vassilios Myrianthopoulos

4

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11

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Paul Greengard

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6 December 2017

Prokopios Magiatis

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Prokopios Magiatis

2

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Alexios-Leandros Skaltsounis

3

object named as

Alexios-Leandros Skaltsounis

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Europe PubMed Central

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6 December 2017

12

object named as

Laurent Meijer

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6 December 2017

author name string

Panagiotis Polychronopoulos

1

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6 December 2017

Aldo Tarricone

6

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6 December 2017

S Mark Roe

8

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6 December 2017

Maryse Leost

10

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6 December 2017

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publication date

1 February 2004

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6 December 2017

Journal of Medicinal Chemistry

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6 December 2017

47

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6 December 2017

4

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Europe PubMed Central

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6 December 2017

935-946

1 reference

Europe PubMed Central

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6 December 2017

A decade of CDK5.

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Macromodel?an integrated software system for modeling organic and bioorganic molecules using molecular mechanics

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Designing inhibitors of cyclin-dependent kinases

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ATP site-directed competitive and irreversible inhibitors of protein kinases

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The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture.

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To cycle or not to cycle: a critical decision in cancer.

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The GSK3 beta signaling cascade and neurodegenerative disease.

1 reference

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Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest

1 reference

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Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

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A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors

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Tyrian Purple: 6,6’-Dibromoindigo and Related Compounds

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Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle

1 reference

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Identifying in vivo targets of cyclin-dependent kinase inhibitors by affinity chromatography

1 reference

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The protein kinase complement of the human genome

1 reference

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The aryl hydrocarbon receptor in anticancer drug discovery: friend or foe?

1 reference

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GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 reference

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Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

1 reference

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Inhibitors of glycogen synthase kinase-3: future therapy for unmet medical needs?

1 reference

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Structure and regulation of the CDK5-p25(nck5a) complex

1 reference

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Pharmacological inhibitors of cyclin-dependent kinases

1 reference

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Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate

1 reference

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Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors.

1 reference

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Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

1 reference

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Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China

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Crystal structure of cyclin-dependent kinase 2

1 reference

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Protein kinases as therapeutic targets

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Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells

1 reference

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Protein kinases as drug targets in parasitic protozoa

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Alzheimer's disease: Mental plaque removal

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Purification of GSK-3 by affinity chromatography on immobilized axin

1 reference

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Identifiers

10.1021/JM031016D

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

ResearchGate publication ID

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