(Q38956908)

7 September 2017

title

The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A. (English)

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7 September 2017

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5

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7 September 2017

Marco Corazzari

2

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author name string

Serafina Oliverio

1

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7 September 2017

Claudia Sestito

3

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7 September 2017

Lucia Piredda

4

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7 September 2017

Mauro Piacentini

6

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7 September 2017

publication date

14 September 2014

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7 September 2017

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7 September 2017

volume

46

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7 September 2017

issue

12

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7 September 2017

page(s)

2767-2776

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https://scigraph.springernature.com/pub.10.1007/s00726-014-1821-0

7 September 2017

exact match

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cites work

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eIF5A isoforms and cancer: two brothers for two functions?

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Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells.

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Transglutaminase 2 is involved in autophagosome maturation

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Induction of autophagy by spermidine promotes longevity

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Regulation of autophagy in mammals and its interplay with apoptosis.

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Polyamines and cancer: old molecules, new understanding

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Oncogenic role of eIF-5A2 in the development of ovarian cancer

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Combining the endoplasmic reticulum stress-inducing agents bortezomib and fenretinide as a novel therapeutic strategy for metastatic melanoma

21 January 2018

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Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor

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Modulation of cellular function by polyamines

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Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth

21 January 2018

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Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression

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The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation

21 January 2018

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21 January 2018

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Effect of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on endothelial cell growth, differentiation and apoptosis

21 January 2018

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N(1)-guanyl-1,7,-diamineoheptane, an inhibitor of deoxyhypusine synthase, suppresses differentiation and induces apoptosis via mitochondrial and AMPK pathways in immortalized and malignant human oral keratinocytes

21 January 2018

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Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification

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Spermidine: a novel autophagy inducer and longevity elixir

21 January 2018

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The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice

21 January 2018

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Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells

21 January 2018

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Eukaryotic translation initiation factor 5A small interference RNA-liposome complexes reduce inflammation and increase survival in murine models of severe sepsis and acute lung injury

21 January 2018

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Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

21 January 2018

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Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response.

21 January 2018

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The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Polyamines in mammalian ageing: an oncological problem, too? A review

21 January 2018

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Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae

21 January 2018

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Effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture

21 January 2018

1 reference

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Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-014-1821-0

Modulation of eIF5A expression using SNS01 nanoparticles inhibits NF-κB activity and tumor growth in murine models of multiple myeloma

21 January 2018

1 reference

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Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-014-1821-0

Spermidine may decrease ER stress in pancreatic beta cells and may reduce apoptosis via activating AMPK dependent autophagy pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-014-1821-0

Autophagosome formation: core machinery and adaptations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-014-1821-0

A single amino acid substitution in yeast eIF-5A results in mRNA stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-014-1821-0

10.1007/S00726-014-1821-0

21 January 2018

Identifiers

DOI

1 reference

7 September 2017

1 reference