(Q38968679)

8 September 2017

title

The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity (English)

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8 September 2017

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7

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8 September 2017

Patrícia S. Guerreiro

Patrícia Guerreiro

4

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Susana A Gonçalves

Susana Gonçalves

2

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Duarte C. Barral

Duarte C Barral

11

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Salvador Ventura

Salvador Ventura

9

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author name string

Oldriska Chutna

1

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8 September 2017

Anna Villar-Piqué

3

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8 September 2017

Zrinka Marijanovic

5

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8 September 2017

Tiago Mendes

6

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8 September 2017

Evangelia Emmanouilidou

8

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8 September 2017

Jochen Klucken

10

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8 September 2017

Flaviano Giorgini

12

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8 September 2017

Kostas Vekrellis

13

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8 September 2017

Tiago F Outeiro

14

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8 September 2017

publication date

4 August 2014

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8 September 2017

number of pages

14

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based on heuristic

inferred from page(s)

published in

Human Molecular Genetics

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8 September 2017

volume

23

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8 September 2017

issue

25

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8 September 2017

page(s)

6732-6745

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Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.

8 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

The genetics of Parkinson's syndromes: a critical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Alpha-synuclein: from secretion to dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

α-Synuclein oligomers and clinical implications for Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Lipid rafts mediate the synaptic localization of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

In vivo demonstration that alpha-synuclein oligomers are toxic

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Activity-dependent secretion of alpha-synuclein by enteric neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Regulation of G protein-coupled receptor trafficking and signaling by Rab GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Rab GTPases as coordinators of vesicle traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Rab11, a small GTPase associated with both constitutive and regulated secretory pathways in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Rab11 regulates recycling through the pericentriolar recycling endosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Rab11 regulates the compartmentalization of early endosomes required for efficient transport from early endosomes to the trans-golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Secretion of soluble vascular endothelial growth factor receptor 1 (sVEGFR1/sFlt1) requires Arf1, Arf6, and Rab11 GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Sorting and recycling of cell surface receptors and endocytosed ligands: The asialoglycoprotein and transferrin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Extracellular vesicles: exosomes, microvesicles, and friends

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Arrivals and departures at the plasma membrane: direct and indirect transport routes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU391

21 January 2018

Identifiers

DOI

10.1093/HMG/DDU391

1 reference

8 September 2017

1 reference