(Q38973867)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25041786%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Acute myeloid leukemia impairs natural killer cells through the formation of a deficient cytotoxic immunological synapse (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25041786%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

0 references

1 reference

acute myeloid leukemia

1 reference

8

1 reference

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10 March 2020

Nicolas Dulphy

9

1 reference

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10 March 2020

1

Zena Khaznadar

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25041786%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

2

Guylaine Henry

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25041786%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

6

Nicolas Boissel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25041786%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

author name string

Niclas Setterblad

3

1 reference

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10 March 2020

Sophie Agaugue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25041786%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

Emmanuel Raffoux

5

1 reference

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10 March 2020

Hervé Dombret

7

1 reference

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10 March 2020

language of work or name

English

0 references

publication date

4 September 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25041786%20AND%20SRC:MED&resulttype=core&format=json

European Journal of Immunology

10 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25041786%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

volume

44

1 reference

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10 March 2020

issue

10

1 reference

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10 March 2020

page(s)

3068-3080

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25041786%20AND%20SRC:MED&resulttype=core&format=json

Human natural killer cells

10 March 2020

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Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing

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NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence

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Human breast tumor cells induce self-tolerance mechanisms to avoid NKG2D-mediated and DNAM-mediated NK cell recognition

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CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia

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Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer

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CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells.

21 January 2018

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Acute myeloid leukaemia cells secrete a soluble factor that inhibits T and NK cell proliferation but not cytolytic function--implications for the adoptive immunotherapy of leukaemia

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The mature activating natural killer cell immunologic synapse is formed in distinct stages

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LFA-1 contributes an early signal for NK cell cytotoxicity.

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Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells.

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Adhesion to target cells is disrupted by the killer cell inhibitory receptor.

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Lytic granule polarization, rather than degranulation, is the preferred target of inhibitory receptors in NK cells

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Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity

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Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity

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Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells

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IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect

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7 January 2021

A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission

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7 January 2021

Early immunophenotypical evaluation of minimal residual disease in acute myeloid leukemia identifies different patient risk groups and may contribute to postinduction treatment stratification

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7 January 2021

Renal cell carcinoma-infiltrating natural killer cells express differential repertoires of activating and inhibitory receptors and are inhibited by specific HLA class I allotypes

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7 January 2021