Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q38978817)
Watch
English
Measuring error rates in genomic perturbation screens: gold standards for human functional genomics
scientific article
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
title
Measuring error rates in genomic perturbation screens: gold standards for human functional genomics
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
main subject
genomics
1 reference
based on heuristic
inferred from title
functional genomics
1 reference
based on heuristic
inferred from title
author
Traver Hart
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
Robert Rottapel
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
Jason Moffat
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
author name string
Kevin R Brown
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
Fabrice Sircoulomb
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
publication date
1 July 2014
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
published in
Molecular Systems Biology
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
volume
10
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
page(s)
733
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
cites work
Genome-scale CRISPR-Cas9 knockout screening in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Genetic screens in human cells using the CRISPR-Cas9 system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Finding the active genes in deep RNA-seq gene expression studies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
A reversible gene trap collection empowers haploid genetics in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
STOP gene Phactr4 is a tumor suppressor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
RNA-guided human genome engineering via Cas9
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Multiplex genome engineering using CRISPR/Cas systems
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
A census of human soluble protein complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Cancer vulnerabilities unveiled by genomic loss
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Evolution and functional impact of rare coding variation from deep sequencing of human exomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Defining the role of essential genes in human disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
RNA sequencing reveals two major classes of gene expression levels in metazoan cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Network properties of human disease genes with pleiotropic effects
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Haploid genetic screens in human cells identify host factors used by pathogens
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Highly parallel identification of essential genes in cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Why do hubs in the yeast protein interaction network tend to be essential: reexamining the connection between the network topology and essentiality
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Null mutations in human and mouse orthologs frequently result in different phenotypes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Proportionally more deleterious genetic variation in European than in African populations.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Cancer proliferation gene discovery through functional genomics.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Off-target effects associated with long dsRNAs in Drosophila RNAi screens
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Further understanding human disease genes by comparing with housekeeping genes and other genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Analyzing protein function on a genomic scale: the importance of gold-standard positives and negatives for network prediction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Genome-wide RNAi analysis of growth and viability in Drosophila cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
One hundred years of mouse genetics: an intellectual history. I. The classical period (1902-1980).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Role of duplicate genes in genetic robustness against null mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Functional profiling of the Saccharomyces cerevisiae genome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Lethality and centrality in protein networks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
STK33 kinase activity is nonessential in KRAS-dependent cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
9 September 2017
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
14 September 2017
Profiling essential genes in human mammary cells by multiplex RNAi screening
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
14 September 2017
Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
17 June 2018
How complete are current yeast and human protein-interaction networks?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
17 June 2018
Molecular biology. Use and abuse of RNAi to study mammalian gene function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
21 August 2018
The complex relationship of gene duplication and essentiality.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
21 August 2018
Minimizing the risk of reporting false positives in large-scale RNAi screens
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299491
retrieved
2 December 2018
ON A MODIFIED MENDELIAN RATIO AMONG YELLOW MICE
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24987113
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.15252/MSB.20145216
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PMC publication ID
4299491
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PubMed publication ID
24987113
1 reference
stated in
Europe PubMed Central
PMC publication ID
4299491
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
ResearchGate publication ID
263670325
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit