(Q38998415)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27812983%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

review article

1 reference

title

AMPK as a Pro-longevity Target (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27812983%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27812983%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

author name string

Kristopher Burkewitz

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27812983%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Heather J M Weir

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27812983%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

publication date

1 January 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27812983%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27812983%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

volume

107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27812983%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

page(s)

227-256

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27812983%20AND%20SRC:MED&resulttype=core&format=json

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

26 March 2020

cites work

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The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

21 January 2018

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Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans.

21 January 2018

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Resveratrol improves health and survival of mice on a high-calorie diet

21 January 2018

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AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging

21 January 2018

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Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.

21 January 2018

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

21 January 2018

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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

21 January 2018

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The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

21 January 2018

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

21 January 2018

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

21 January 2018

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Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans

21 January 2018

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Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span.

21 January 2018

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

21 January 2018

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Loss of a neural AMP-activated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions

21 January 2018

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Lifespan regulation by evolutionarily conserved genes essential for viability

21 January 2018

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Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways.

21 January 2018

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p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake

21 January 2018

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Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes

21 January 2018

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Rates of behavior and aging specified by mitochondrial function during development

21 January 2018

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Autophagy genes mediate the effect of calcineurin on life span in C. elegans

21 January 2018

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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

21 January 2018

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Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

21 January 2018

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Metformin and reduced risk of cancer in diabetic patients

21 January 2018

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Regulation of longevity and stress resistance by Sch9 in yeast

21 January 2018

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Promoting health and longevity through diet: from model organisms to humans

21 January 2018

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Extending healthy life span--from yeast to humans

21 January 2018

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

21 January 2018

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Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt

21 January 2018

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Substantial health and economic returns from delayed aging may warrant a new focus for medical research

21 January 2018

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Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

21 January 2018

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Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

21 January 2018

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An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

21 January 2018

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The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor

21 January 2018

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Calorie restriction and sirtuins revisited

21 January 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

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The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.

21 January 2018

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

21 January 2018

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

21 January 2018

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21 January 2018

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The ancient drug salicylate directly activates AMP-activated protein kinase

21 January 2018

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Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond

21 January 2018

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daf-16 protects the nematode Caenorhabditis elegans during food deprivation.

21 January 2018

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AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply

21 January 2018

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Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

21 January 2018

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Obesity accelerates epigenetic aging of human liver

21 January 2018

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A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction

21 January 2018

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Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans.

21 January 2018

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Mitonuclear protein imbalance as a conserved longevity mechanism

21 January 2018

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

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Evidence for a common mechanism of SIRT1 regulation by allosteric activators

21 January 2018

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

21 January 2018

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TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

21 January 2018

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Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

21 January 2018

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Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.

21 January 2018

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Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila

21 January 2018

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mTOR is a key modulator of ageing and age-related disease

21 January 2018

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

21 January 2018

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The sirtuin SIRT6 regulates lifespan in male mice

21 January 2018

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

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The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

21 January 2018

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A C. elegans mutant that lives twice as long as wild type

21 January 2018

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AMPK connects energy stress to PIK3C3/VPS34 regulation

21 January 2018

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

21 January 2018

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Orchestrating the network of molecular pathways affecting aging: Role of nonselective autophagy and mitophagy

21 January 2018

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Determination of life-span in Caenorhabditis elegans by four clock genes

21 January 2018

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SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation

21 January 2018

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Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans

21 January 2018

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mTOR signaling in growth control and disease

21 January 2018

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AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

21 January 2018

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Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice.

21 January 2018

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Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

21 January 2018

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Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

21 January 2018

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21 January 2018

The hallmarks of aging

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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

21 January 2018

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Aging and survival: the genetics of life span extension by dietary restriction.

21 January 2018

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Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

21 January 2018

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Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans

21 January 2018

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Metformin improves healthspan and lifespan in mice

21 January 2018

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Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

21 January 2018

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Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.

21 January 2018

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C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension

21 January 2018

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Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

21 January 2018

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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

21 January 2018

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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

21 January 2018

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Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

21 January 2018

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Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span

21 January 2018

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Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

21 January 2018

1 reference

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Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

21 January 2018

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Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

21 January 2018

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Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

21 January 2018

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PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

21 January 2018

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Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

21 January 2018

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

21 January 2018

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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

21 January 2018

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Repurposing metformin: an old drug with new tricks in its binding pockets

21 January 2018

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Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog.

21 January 2018

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Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

21 January 2018

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Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans

21 January 2018

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AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

21 January 2018

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21 January 2018

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Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.

21 January 2018

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

21 January 2018

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

21 January 2018

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

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Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila

21 January 2018

1 reference

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Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

21 January 2018

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Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

21 January 2018

1 reference

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Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies.

21 January 2018

1 reference

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Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

21 January 2018

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Functionally significant insulin-like growth factor I receptor mutations in centenarians

21 January 2018

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eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

21 January 2018

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Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

21 January 2018

1 reference

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DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-43589-3_10

AMPK modulates tissue and organismal aging in a non-cell-autonomous manner

21 January 2018

1 reference

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AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

21 January 2018

1 reference

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Genetics: influence of TOR kinase on lifespan in C. elegans

21 January 2018

1 reference

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Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway.

21 January 2018

1 reference

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The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

21 January 2018

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Fat metabolism links germline stem cells and longevity in C. elegans

21 January 2018

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D-Glucosamine supplementation extends life span of nematodes and of ageing mice

21 January 2018

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

21 January 2018

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Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-43589-3_10

Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-43589-3_10

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-43589-3_10

Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-43589-3_10

Mitochondrial response to nutrient availability and its role in metabolic disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-43589-3_10

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-43589-3_10

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-43589-3_10

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-43589-3_10

Coupling of GCN4 mRNA translational activation with decreased rates of polypeptide chain initiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-43589-3_10

Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-43589-3_10

10.1007/978-3-319-43589-3_10

31 March 2020

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27812983%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference