(Q39023942)

English

The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G₁ cell-cycle arrest and not a direct effect on BIK protein stability

scientific article published on May 2014

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scholarly article

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Europe PubMed Central

PubMed publication ID

8 September 2017

The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G₁ cell-cycle arrest and not a direct effect on BIK protein stability (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

2

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24527759%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Matthew J Sale

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24527759%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

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publication date

1 May 2014

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Europe PubMed Central

PubMed publication ID

8 September 2017

Biochemical Journal

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24527759%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

459

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24527759%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24527759%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

513-524

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24527759%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

The BCL-2 family reunion

1 reference

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21 January 2018

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

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21 January 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Tumour cell survival signalling by the ERK1/2 pathway

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1.

1 reference

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21 January 2018

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance

1 reference

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21 January 2018

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Role of Bim in the survival pathway induced by Raf in epithelial cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.

1 reference

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21 January 2018

ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Structure of the UBA domain of Dsk2p in complex with ubiquitin molecular determinants for ubiquitin recognition.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Isolation and characterization of possible target proteins responsible for neurite outgrowth induced by a tripeptide aldehyde in PC12H cells.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

The CASBAH: a searchable database of caspase substrates

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

CASVM: web server for SVM-based prediction of caspase substrates cleavage sites

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

That which does not kill me makes me stronger; combining ERK1/2 pathway inhibitors and BH3 mimetics to kill tumour cells and prevent acquired resistance.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Evidence for involvement of BH3-only proapoptotic members in adenovirus-induced apoptosis

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

BH3 domains other than Bim and Bid can directly activate Bax/Bak

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131346

21 January 2018

Identifiers

10.1042/BJ20131346

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24527759%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24527759%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

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