(Q39025392)

8 September 2017

1 reference

title

Organization and functions of mGlu and GABAB receptor complexes (English)

1 reference

8 September 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27905440%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Bernhard Bettler

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27905440%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

2

Bernhard Bettler

1 reference

8 September 2017

Jean-Philippe Pin

1

1 reference

8 September 2017

language of work or name

English

0 references

publication date

1 December 2016

1 reference

8 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27905440%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

volume

540

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27905440%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

issue

7631

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27905440%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

60-68

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27905440%20AND%20SRC:MED&resulttype=core&format=json

Regulation of neuronal GABA(B) receptor functions by subunit composition

6 June 2020

cites work

1 reference

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Metabotropic glutamate receptors: physiology, pharmacology, and disease

21 January 2018

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Chemistry and pharmacology of GABAB receptor ligands

21 January 2018

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Development of allosteric modulators of GPCRs for treatment of CNS disorders

21 January 2018

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Structures of mGluRs shed light on the challenges of drug development of allosteric modulators

21 January 2018

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Dimers and beyond: The functional puzzles of class C GPCRs.

21 January 2018

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GABAB receptors - the first 7TM heterodimers.

21 January 2018

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Phospho-dependent Accumulation of GABABRs at Presynaptic Terminals after NMDAR Activation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE20566

A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits

21 January 2018

1 reference

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Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics.

21 January 2018

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Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function

21 January 2018

1 reference

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Protein complexes are under evolutionary selection to assemble via ordered pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

GABAB receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Heterodimeric coiled-coil interactions of human GABAB receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Segregation of family A G protein-coupled receptor protomers in the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Structures of the extracellular regions of the group II/III metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Structural mechanism of ligand activation in human GABAB receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Conformational dynamics of a class C G-protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Interdomain movements in metabotropic glutamate receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Asymmetry of GPCR oligomers supports their functional relevance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Trans-activation between 7TM domains: implication in heterodimeric GABABreceptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

A negative allosteric modulator modulates GABAB-receptor signalling through GB2 subunits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Arrestins come of age: a personal historical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Molecular mechanisms that desensitize metabotropic glutamate receptor signaling: an overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Phosphorylation-independent desensitization of GABA(B) receptor by GRK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

The metabotropic glutamate receptor mGluR5 is endocytosed by a clathrin-independent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

GABAB receptors-associated proteins: potential drug targets in neurological disorders?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Molecular diversity, trafficking and subcellular localization of GABAB receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

GABAB receptor trafficking and interacting proteins: targets for the development of highly specific therapeutic strategies to treat neurological disorders?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

GPCR interacting proteins (GIPs) in the nervous system: Roles in physiology and pathologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Metabotropic glutamate receptors and interacting proteins: evolving drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Auxiliary GABAB receptor subunits uncouple G protein βγ subunits from effector channels to induce desensitization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Mode of coupling between the β-adrenergic receptor and adenylate cyclase in turkey erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Pharmacological characterization of GABAB receptor subtypes assembled with auxiliary KCTD subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

GABA blocks pathological but not acute TRPV1 pain signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Calsyntenins mediate TGN exit of APP in a kinesin-1-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Impairment of GABAB receptor dimer by endogenous 14-3-3ζ in chronic pain conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Rapid antidepressants stimulate the decoupling of GABA(B) receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

A critical role of striatal A2A R-mGlu5 R interactions in modulating the psychomotor and drug-seeking effects of methamphetamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

The Effective Application of Biased Signaling to New Drug Discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Homeostatic scaling requires group I mGluR activation mediated by Homer1a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Novel Allosteric Modulators of G Protein-coupled Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Cellular, synaptic, and circuit effects of antibodies in autoimmune CNS synaptopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Visualizing protein partnerships in living cells and organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

The Sushi domains of GABAB receptors function as axonal targeting signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Differential binding of calmodulin to group I metabotropic glutamate receptors regulates receptor trafficking and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Preso1 dynamically regulates group I metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

PKC phosphorylation regulates mGluR5 trafficking by enhancing binding of Siah-1A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20566

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

21 January 2018

1 reference

12 December 2020

Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins

1 reference

12 December 2020

A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators

1 reference

12 December 2020

The oligomeric state sets GABA(B) receptor signalling efficacy

1 reference

12 December 2020

Stability of GABAB receptor oligomers revealed by dual TR-FRET and drug-induced cell surface targeting.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE20566

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27905440%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference