(Q24338769)

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Vsevolod Katritch

8

0 references

Vadim Cherezov

10

0 references

Huixian Wu

Huixian Wu

1

0 references

Karen J. Gregory

Karen J Gregory

3

0 references

Jens Meiler

Jens Meiler

9

0 references

Raymond C. Stevens

Raymond C Stevens

12

0 references

Colleen M. Niswender

7

Colleen M Niswender

0 references

P. Jeffrey Conn

11

P Jeffrey Conn

0 references

Hyekyung P Cho

5

Hyekyung P Cho

0 references

Gye Won Han

4

Gye Won Han

0 references

author name string

Chong Wang

2

0 references

Yan Xia

Structure of class B GPCR corticotropin-releasing factor receptor 1

6

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language of work or name

English

0 references

publication date

4 April 2014

0 references

published in

Science

0 references

volume

344

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issue

6179

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page(s)

58-64

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cites work

1 reference

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Structure of the human glucagon class B G-protein-coupled receptor

19 March 2017

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Structure of the human κ-opioid receptor in complex with JDTic

19 March 2017

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Structure of an agonist-bound human A2A adenosine receptor

19 March 2017

1 reference

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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

19 March 2017

1 reference

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Structures of the extracellular regions of the group II/III metabotropic glutamate receptors

19 March 2017

1 reference

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Cyclothiazide selectively inhibits mGluR1 receptors interacting with a common allosteric site for non-competitive antagonists

19 March 2017

1 reference

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Mechanism-based approaches to treating fragile X

19 March 2017

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Structure of the human smoothened receptor bound to an antitumour agent

19 March 2017

1 reference

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Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

19 March 2017

1 reference

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Crystal structure of rhodopsin: A G protein-coupled receptor

19 March 2017

1 reference

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CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding

19 March 2017

1 reference

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Sequence and expression of a metabotropic glutamate receptor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Molecular diversity of glutamate receptors and implications for brain function

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard

19 March 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1249489

Refinement of macromolecular structures by the maximum-likelihood method

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1249489

Features and development of Coot

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1249489

Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1249489

Structural diversity of G protein-coupled receptors and significance for drug discovery

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Crystallizing membrane proteins using lipidic mesophases

7 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard

22 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0

22 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Structure-function of the G protein-coupled receptor superfamily

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Interdomain movements in metabotropic glutamate receptor activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Dimers and beyond: The functional puzzles of class C GPCRs.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Metabotropic glutamate receptors: physiology, pharmacology, and disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTID

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3991565

Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist

30 May 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4H-chromen-4-one

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

ROSETTALIGAND: protein-small molecule docking with full side-chain flexibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Radiosynthesis and preliminary evaluation of 4-[18F]fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as a new positron emission tomography ligand for metabotropic glutamate receptor subtype 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Assessment and challenges of ligand docking into comparative models of G-protein coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Modeling and Mutagenesis of the Binding Site of Calhex 231, a Novel Negative Allosteric Modulator of the Extracellular Ca2+-sensing Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

Point mutations in the transmembrane region of GABAB2 facilitate activation by the positive modulator N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the absence of the GABAB1 subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249489

The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate recepto

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24603153

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1249489

1 reference

ADS bibcode

2014Sci...344...58W

0 references

1 reference

1 reference

PubMed publication ID

24603153

1 reference