(Q39036597)

8 September 2017

title

TRAF6 stimulates the tumor-promoting effects of TGFβ type I receptor through polyubiquitination and activation of presenilin 1. (English)

1 reference

8 September 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24399296%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Reshma Sundar

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24399296%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Marene Landström

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24399296%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Yabing Mu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24399296%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Anders Wallenius

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24399296%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Guangxiang Zang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24399296%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Anders Bergh

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24399296%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Carl-Henrik Heldin

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24399296%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

publication date

7 January 2014

1 reference

8 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24399296%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24399296%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

307

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24399296%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

ra2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24399296%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Mechanism of activation of the TGF-beta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

TGFβ signalling in context

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Ubiquitin-mediated activation of TAK1 and IKK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

TGF-beta uses the E3-ligase TRAF6 to turn on the kinase TAK1 to kill prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

The TAK1-TRAF6 signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Non-Smad signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

gamma-secretases: from cell biology to therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Pathological and physiological functions of presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Presenilin function and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Assembly, trafficking and function of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Association between Presenilin-1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Gamma-secretase: proteasome of the membrane?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Direct observation of individual endogenous protein complexes in situ by proximity ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Dissection of the Golgi complex. II. Density separation of specific Golgi functions in virally infected cells treated with monensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Gamma-secretase and the intramembrane proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

JAGGED1 expression is associated with prostate cancer metastasis and recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Turning it up a Notch: cross-talk between TGF beta and Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

TRAF6 is a signal transducer for interleukin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Different signals mediate transforming growth factor-beta 1-induced growth inhibition and extracellular matrix production in prostatic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004207