(Q39087734)

9 September 2017

title

In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection (English)

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9 September 2017

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9 September 2017

S Bonte

3

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Stijn Vanhee

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S Vanhee

5

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Tom Taghon

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T Taghon

11

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Georges Leclercq

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G Leclercq

12

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author name string

S Snauwaert

1

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9 September 2017

G Verstichel

2

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9 September 2017

G Goetgeluk

4

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9 September 2017

Y Van Caeneghem

6

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9 September 2017

K De Mulder

7

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9 September 2017

C Heirman

8

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9 September 2017

H Stauss

9

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9 September 2017

M H M Heemskerk

10

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9 September 2017

J Plum

13

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A W Langerak

14

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9 September 2017

K Thielemans

15

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T Kerre

16

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9 September 2017

publication date

4 October 2013

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9 September 2017

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9 September 2017

volume

28

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9 September 2017

issue

4

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9 September 2017

page(s)

830-841

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T cell receptor gene therapy for cancer

9 September 2017

cites work

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CD3 limits the efficacy of TCR gene therapy in vivo

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Human bone marrow CD34+ progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment

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Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells

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Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors

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Extrathymic generation of tumor-specific T cells from genetically engineered human hematopoietic stem cells via Notch signaling

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Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment

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Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation

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Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch

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Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer

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Selecting highly affine and well-expressed TCRs for gene therapy of melanoma

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ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

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Wilms tumor gene (WT1) expression as a panleukemic marker

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WT1 in acute leukemia, chronic myelogenous leukemia and myelodysplastic syndrome: therapeutic potential of WT1 targeted therapies

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Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

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Downregulation of CD1 marks acquisition of functional maturation of human thymocytes and defines a control point in late stages of human T cell development

21 January 2018

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Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus

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CXCR3 and alphaEbeta7 integrin identify a subset of CD8+ mature thymocytes that share phenotypic and functional properties with CD8+ gut intraepithelial lymphocytes

21 January 2018

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New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling.

21 January 2018

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Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150.

21 January 2018

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T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

21 January 2018

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Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway

21 January 2018

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Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

21 January 2018

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Adoptive immunotherapy for cancer: building on success

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IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.

21 January 2018

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Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells

21 January 2018

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21 January 2018

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T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α- and β-genes

21 January 2018

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Characterization of distinct stages during the differentiation of human CD69+CD3+ thymocytes and identification of thymic emigrants.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24091848

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Human thymocytes become lineage committed at an early postselection CD69+ stage, before the onset of functional maturation.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24091848

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/LEU.2013.285

1 reference

9 September 2017

1 reference