(Q39092314)

English

TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling

scientific article published on 6 May 2013

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

prostate cancer

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based on heuristic

inferred from title

author name string

Naokazu Ibuki

1

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Europe PubMed Central

PubMed publication ID

9 September 2017

Mazyar Ghaffari

2

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

Mitali Pandey

3

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

Irene Iu

4

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Europe PubMed Central

PubMed publication ID

9 September 2017

Ladan Fazli

5

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Europe PubMed Central

PubMed publication ID

9 September 2017

Masahide Kashiwagi

6

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Europe PubMed Central

PubMed publication ID

9 September 2017

Hideaki Tojo

7

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

Osamu Nakanishi

8

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Europe PubMed Central

PubMed publication ID

9 September 2017

Martin E Gleave

9

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9 September 2017

Michael E Cox

10

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9 September 2017

language of work or name

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publication date

6 May 2013

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9 September 2017

International Journal of Cancer

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9 September 2017

133

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9 September 2017

8

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9 September 2017

1955-1966

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Europe PubMed Central

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9 September 2017

Cancer statistics, 2006

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Increased survival with enzalutamide in prostate cancer after chemotherapy

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

GLI2 knockdown using an antisense oligonucleotide induces apoptosis and chemosensitizes cells to paclitaxel in androgen-independent prostate cancer

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

The hedgehog signaling network

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

The Hedgehog response network: sensors, switches, and routers

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Activation of heterotrimeric G proteins by Smoothened

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

A paracrine requirement for hedgehog signalling in cancer

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Activation of the hedgehog pathway in advanced prostate cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Hedgehog/Ras interactions regulate early stages of pancreatic cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Sonic Hedgehog signaling in advanced prostate cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Comparative expression of Hedgehog ligands at different stages of prostate carcinoma progression

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Lack of demonstrable autocrine hedgehog signaling in human prostate cancer cell lines

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Hedgehog signaling promotes prostate xenograft tumor growth

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Active sonic hedgehog signaling between androgen independent human prostate cancer cells and normal/benign but not cancer-associated prostate stromal cells

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts

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https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Polymeric micellar paclitaxel phosphorylates Bcl-2 and induces apoptotic regression of androgen-independent LNCaP prostate tumors.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Expression of hedgehog pathway components in prostate carcinoma microenvironment: shifting the balance towards autocrine signalling

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Basal cell carcinomas: attack of the hedgehog

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Sonic hedgehog regulates prostatic growth and epithelial differentiation

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Androgens regulate Hedgehog signalling and proliferation in androgen-dependent prostate cells.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

The hedgehog pathway inhibitor cyclopamine increases levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo).

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Targeting the Hedgehog pathway in cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Steroid hormonal regulation of growth, prostate specific antigen secretion, and transcription mediated by the mutated androgen receptor in CWR22Rv1 human prostate carcinoma cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Repurposing itraconazole as a treatment for advanced prostate cancer: a noncomparative randomized phase II trial in men with metastatic castration-resistant prostate cancer.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Tissue repair and stem cell renewal in carcinogenesis

1 reference

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21 January 2018

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28193

21 January 2018

Identifiers

10.1002/IJC.28193

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

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