(Q39095019)

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Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides

scientific article published on 14 September 2013

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Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5839143

Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides (English)

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Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5839143

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non-small-cell lung carcinoma

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Ravi Salgia

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20 June 2018

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Neelu Puri

1

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Europe PubMed Central

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20 June 2018

http://europepmc.org/abstract/PMC/5839143

Ryan T Pitman

2

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Europe PubMed Central

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20 June 2018

http://europepmc.org/abstract/PMC/5839143

Richard E Mulnix

3

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20 June 2018

http://europepmc.org/abstract/PMC/5839143

Terrianne Erickson

4

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20 June 2018

http://europepmc.org/abstract/PMC/5839143

Audra N Iness

5

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Europe PubMed Central

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20 June 2018

http://europepmc.org/abstract/PMC/5839143

Connie Vitali

6

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20 June 2018

http://europepmc.org/abstract/PMC/5839143

Yutong Zhao

7

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20 June 2018

http://europepmc.org/abstract/PMC/5839143

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publication date

14 September 2013

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20 June 2018

http://europepmc.org/abstract/PMC/5839143

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Europe PubMed Central

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20 June 2018

http://europepmc.org/abstract/PMC/5839143

343

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Europe PubMed Central

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20 June 2018

http://europepmc.org/abstract/PMC/5839143

1

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Europe PubMed Central

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http://europepmc.org/abstract/PMC/5839143

14-23

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Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5839143

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma

1 reference

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22 June 2018

Telomere-homologous G-rich oligonucleotides sensitize human ovarian cancer cells to TRAIL-induced growth inhibition and apoptosis

1 reference

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22 June 2018

Senescence regulation by the p53 protein family

1 reference

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22 June 2018

Novel anticancer therapeutics targeting telomerase

1 reference

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22 June 2018

Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2.

1 reference

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22 June 2018

Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells

1 reference

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22 June 2018

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop

1 reference

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22 June 2018

Personalized treatment of lung cancer

1 reference

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22 June 2018

T-oligos inhibit growth and induce apoptosis in human ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer

1 reference

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22 June 2018

E2F-1 Directly Regulates Thrombospondin 1 Expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Radiosensitization of mammary carcinoma cells by telomere homolog oligonucleotide pretreatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

p53-dependent anticancer effects of leptomycin B on lung adenocarcinoma

1 reference

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22 June 2018

Inhibition of melanoma angiogenesis by telomere homolog oligonucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Telomerase-based therapies emerging slowly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Telomeric DNA induces p53-dependent reactive oxygen species and protects against oxidative damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

p53 and E2f: partners in life and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

T-oligo induces apoptosis in advanced prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

The combined status of ATM and p53 link tumor development with therapeutic response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: mechanism and therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Immunohistochemistry in the evaluation of neovascularization in tumor xenografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Telomerase inhibitors and 'T-oligo' as cancer therapeutics: contrasting molecular mechanisms of cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Review: side effects of approved molecular targeted therapies in solid cancers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Telomerase targeted oligonucleotide thio-phosphoramidates in T24-luc bladder cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Regulation of tumor angiogenesis by thrombospondin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

1 reference

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22 June 2018

Signaling pathway requirements for induction of senescence by telomere homolog oligonucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Telomere-based DNA damage responses: a new approach to melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

p53 protein variants: structural and functional similarities with p63 and p73 isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Toxicity patterns of cytotoxic drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Induction of a p95/Nbs1-mediated S phase checkpoint by telomere 3' overhang specific DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Evidence that exposure of the telomere 3' overhang sequence induces senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Clinical implications of p53 mutations in lung cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Induction of apoptosis by telomere 3' overhang-specific DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Cell cycle arrest is sufficient for p53-mediated tumor regression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Relationship between vessel density and expression of vascular endothelial growth factor and basic fibroblast growth factor in small cell lung cancer in vivo and in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Expression of the vascular endothelial growth factor gene is inhibited by p73.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Comparative analysis of p73 and p53 regulation and effector functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Apoptosis, p53, and tumor cell sensitivity to anticancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

22 June 2018

Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

21 August 2018

Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

21 August 2018

Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

21 August 2018

Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839143

21 August 2018

A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/24041868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/24041868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/24041868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p73 overexpression increases VEGF and reduces thrombospondin-1 production: implications for tumor angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24041868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CANLET.2013.09.010

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5839143

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5839143

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5839143

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