(Q37602510)

21 August 2017

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title

p53 and E2f: partners in life and death (English)

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21 August 2017

Shirley Polager

1

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PubMed ID

19776743

21 August 2017

Doron Ginsberg

series ordinal

2

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PubMed ID

19776743

21 August 2017

language of work or name

English

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publication date

1 October 2009

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21 August 2017

Nature Reviews Cancer

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21 August 2017

9

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21 August 2017

738-748

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21 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrc2718

21 August 2017

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cites work

A complex barcode underlies the heterogeneous response of p53 to stress

1 reference

Nucleolar Arf sequesters Mdm2 and activates p53

31 March 2020

1 reference

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

31 March 2020

1 reference

Tumor spectrum analysis in p53-mutant mice

31 March 2020

1 reference

The E2F transcriptional network: old acquaintances with new faces

31 March 2020

1 reference

E2F - at the crossroads of life and death

31 March 2020

1 reference

E2F1-induced apoptosis: turning killers into therapeutics

31 March 2020

1 reference

Life and death decisions by the E2F transcription factors

31 March 2020

1 reference

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

31 March 2020

1 reference

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

31 March 2020

1 reference

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

31 March 2020

1 reference

The RB and p53 pathways in cancer

31 March 2020

1 reference

E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer.

31 March 2020

1 reference

Amplification and overexpression of E2F3 in human bladder cancer

31 March 2020

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Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome

31 March 2020

1 reference

The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53.

31 March 2020

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Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

31 March 2020

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Stress signals induce transcriptionally inactive E2F-1 independently of p53 and Rb

31 March 2020

1 reference

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

31 March 2020

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

31 March 2020

1 reference

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

31 March 2020

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Chk2 activates E2F-1 in response to DNA damage

31 March 2020

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p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.

31 March 2020

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Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

31 March 2020

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Specific role for p300/CREB-binding protein-associated factor activity in E2F1 stabilization in response to DNA damage

31 March 2020

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Regulation of E2F-1 after DNA damage by p300-mediated acetylation and ubiquitination

31 March 2020

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The ups and downs of SIRT1.

31 March 2020

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Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

31 March 2020

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Negative control of p53 by Sir2alpha promotes cell survival under stress

31 March 2020

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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

31 March 2020

1 reference

The p53-Mdm2 module and the ubiquitin system.

31 March 2020

1 reference

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

31 March 2020

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Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26

31 March 2020

1 reference

Interaction between the retinoblastoma protein and the oncoprotein MDM2

31 March 2020

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Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

31 March 2020

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RB regulates the stability and the apoptotic function of p53 via MDM2

31 March 2020

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The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth

31 March 2020

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MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.

31 March 2020

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Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway

31 March 2020

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Apoptotic and growth-promoting activity of E2F modulated by MDM2

31 March 2020

1 reference

Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.

31 March 2020

1 reference

E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines

31 March 2020

1 reference

Tumor suppression by Ink4a-Arf: progress and puzzles

31 March 2020

1 reference

The INK4a/ARF network in tumour suppression

31 March 2020

1 reference

Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

31 March 2020

1 reference

Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

31 March 2020

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E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest

31 March 2020

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A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

31 March 2020

1 reference

p14ARF links the tumour suppressors RB and p53.

31 March 2020

1 reference

Live or let die: the cell's response to p53

31 March 2020

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Distinct E2F-mediated transcriptional program regulates p14ARF gene expression

31 March 2020

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p19ARF targets certain E2F species for degradation.

31 March 2020

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Human ARF binds E2F1 and inhibits its transcriptional activity.

31 March 2020

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p14(ARF) regulates E2F activity

31 March 2020

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ARF differentially modulates apoptosis induced by E2F1 and Myc.

31 March 2020

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ARF is not required for apoptosis in Rb mutant mouse embryos

31 March 2020

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

31 March 2020

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p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo

31 March 2020

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E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis

31 March 2020

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ATM is a target for positive regulation by E2F-1.

31 March 2020

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Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.

31 March 2020

1 reference

E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1.

31 March 2020

1 reference

Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis

31 March 2020

1 reference

Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.

31 March 2020

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Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage

31 March 2020

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PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells

31 March 2020

1 reference

F-box protein Skp2: a novel transcriptional target of E2F.

31 March 2020

1 reference

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

31 March 2020

1 reference

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

31 March 2020

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The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

31 March 2020

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Skp2 suppresses p53-dependent apoptosis by inhibiting p300.

31 March 2020

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Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

31 March 2020

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Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

31 March 2020

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p53 and E2F-1 cooperate to mediate apoptosis

31 March 2020

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Direct coupling of the cell cycle and cell death machinery by E2F.

31 March 2020

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

31 March 2020

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Apaf-1 is a transcriptional target for E2F and p53

31 March 2020

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Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

31 March 2020

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PUMA, a novel proapoptotic gene, is induced by p53

31 March 2020

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

31 March 2020

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The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1

31 March 2020

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Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

31 March 2020

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Negative regulation of bcl-2 expression by p53 in hematopoietic cells

31 March 2020

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Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

31 March 2020

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Direct repression of the Mcl-1 promoter by E2F1.

31 March 2020

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

31 March 2020

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Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.

31 March 2020

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ASPP1 and ASPP2 are new transcriptional targets of E2F

31 March 2020

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Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene

31 March 2020

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ASPP proteins specifically stimulate the apoptotic function of p53

31 March 2020

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

31 March 2020

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Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development

31 March 2020

1 reference

E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop

31 March 2020

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Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation

31 March 2020

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The E2F1-3 transcription factors are essential for cellular proliferation.

31 March 2020

1 reference

Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

31 March 2020

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pRB plays an essential role in cell cycle arrest induced by DNA damage

31 March 2020

1 reference

E2F mediates sustained G2 arrest and down-regulation of Stathmin and AIM-1 expression in response to genotoxic stress

31 March 2020

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p130/E2F4 binds to and represses the cdc2 promoter in response to p53.

31 March 2020

1 reference

p53 regulation of G(2) checkpoint is retinoblastoma protein dependent

31 March 2020

1 reference

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

31 March 2020

1 reference

The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1

31 March 2020

1 reference

Transcriptional activation of miR-34a contributes to p53-mediated apoptosis

31 March 2020

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A microRNA component of the p53 tumour suppressor network

31 March 2020

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Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

31 March 2020

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MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

31 March 2020

1 reference

E2F3 is the main target gene of the 6p22 amplicon with high specificity for human bladder cancer

31 March 2020

1 reference

The coordinate regulation of the p53 and mTOR pathways in cells

31 March 2020

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BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy

31 March 2020

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E2F1 regulates autophagy and the transcription of autophagy genes

31 March 2020

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Regulation of autophagy by cytoplasmic p53

31 March 2020

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Transcription regulation by mutant p53.

31 March 2020

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Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.

31 March 2020

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p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.

31 March 2020

1 reference

Network motifs: theory and experimental approaches

31 March 2020

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Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53

31 March 2020

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Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.

31 March 2020

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Constitutive expression of E2F-1 leads to p21-dependent cell cycle arrest in S phase of the cell cycle

31 March 2020

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Role for the p53 homologue p73 in E2F-1-induced apoptosis

31 March 2020

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A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

31 March 2020

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Role of the p53-homologue p73 in E2F1-induced apoptosis

31 March 2020

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p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death

31 March 2020

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Classic and novel roles of p53: prospects for anticancer therapy

31 March 2020

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Pocket proteins and cell cycle control

31 March 2020

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

31 March 2020

2 references

31 March 2020

12 December 2020

Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context

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12 December 2020

Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation

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12 December 2020

E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.

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12 December 2020

Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb.

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12 December 2020

Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis

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12 December 2020

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

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12 December 2020

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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12 December 2020

The MDM2 antagonist nutlin-3 sensitizes p53-null neuroblastoma cells to doxorubicin via E2F1 and TAp73.

1 reference

12 December 2020

E2f3 is critical for normal cellular proliferation

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12 December 2020

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice

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12 December 2020

Identifiers

DOI

10.1038/NRC2718

1 reference

21 August 2017

1 reference

PubMed ID

19776743