(Q39098027)

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Mutational analysis identifies residues crucial for homodimerization of myeloid differentiation factor 88 (MyD88) and for its function in immune cells.

scientific article published on 9 September 2013

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20 February 2020

Mutational analysis identifies residues crucial for homodimerization of myeloid differentiation factor 88 (MyD88) and for its function in immune cells (English)

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20 February 2020

mutational analysis

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based on heuristic

inferred from title

5

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20 February 2020

8

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20 February 2020

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Maria Loiarro

1

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20 February 2020

Elisabetta Volpe

2

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20 February 2020

Vito Ruggiero

3

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20 February 2020

Grazia Gallo

4

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20 February 2020

Chiara Maiorino

6

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20 February 2020

Luca Battistini

7

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20 February 2020

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9 September 2013

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20 February 2020

Journal of Biological Chemistry

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20 February 2020

288

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20 February 2020

42

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20 February 2020

30210-30222

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20 February 2020

Pathogen recognition receptors: ligands and signaling pathways by Toll-like receptors

1 reference

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9 September 2017

Molecular basis of NF-κB signaling

1 reference

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9 September 2017

Targeting the Toll-like receptor/interleukin 1 receptor pathway in human diseases: rational design of MyD88 inhibitors.

1 reference

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9 September 2017

Anti-inflammatory therapy in chronic disease: challenges and opportunities

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9 September 2017

Suppression of TLR signaling by targeting TIR domain-containing proteins

1 reference

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9 September 2017

Roles of toll-like receptors in cancer: a double-edged sword for defense and offense

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9 September 2017

MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.

1 reference

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9 September 2017

TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88

1 reference

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9 September 2017

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

1 reference

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9 September 2017

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

1 reference

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9 September 2017

Oncogenically active MYD88 mutations in human lymphoma

1 reference

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9 September 2017

TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.

1 reference

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9 September 2017

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

1 reference

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9 September 2017

Targeting TLR/IL-1R signalling in human diseases.

1 reference

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9 September 2017

The IL-1 family: regulators of immunity

1 reference

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9 September 2017

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

Pyogenic bacterial infections in humans with MyD88 deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

FireDock: a web server for fast interaction refinement in molecular docking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

Toll-like receptor signalling and the clinical benefits that lie within

1 reference

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9 September 2017

The death domain superfamily in intracellular signaling of apoptosis and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

PatchDock and SymmDock: servers for rigid and symmetric docking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

The evolution of vertebrate Toll-like receptors

1 reference

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9 September 2017

Toll-like receptor control of the adaptive immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

1 reference

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9 September 2017

TIRAP: an adapter molecule in the Toll signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

9 September 2017

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

1 reference

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1 reference

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9 September 2017

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

1 reference

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9 September 2017

MyD88, an adapter protein involved in interleukin-1 signaling

1 reference

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Dendritic cells and the control of immunity

1 reference

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9 September 2017

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

1 reference

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9 September 2017

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

1 reference

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9 September 2017

Molecular characterization and modular analysis of human MyD88

1 reference

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9 September 2017

Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling.

1 reference

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9 September 2017

Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal).

1 reference

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14 September 2017

Human monocytoid cells as a model to study Toll-like receptor-mediated activation

1 reference

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14 September 2017

Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway

1 reference

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14 September 2017

The interleukin 1 (IL-1) receptor accessory protein Toll/IL-1 receptor domain: analysis of putative interaction sites in vitro mutagenesis and molecular modeling

1 reference

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14 September 2017

Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

25 September 2017

Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients.

1 reference

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21 August 2018

Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

21 August 2018

FireDock: fast interaction refinement in molecular docking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798488

21 August 2018

Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B

1 reference

https://pubmed.ncbi.nlm.nih.gov/24019529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound

1 reference

https://pubmed.ncbi.nlm.nih.gov/24019529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.490946

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019529%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019529%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019529%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

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