(Q39113154)

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Rational design of resorcylic acid lactone analogues as covalent MNK1/2 kinase inhibitors by tuning the reactivity of an enamide Michael acceptor

scientific article published on 8 August 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 September 2017

Rational design of resorcylic acid lactone analogues as covalent MNK1/2 kinase inhibitors by tuning the reactivity of an enamide Michael acceptor (English)

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Europe PubMed Central

PubMed publication ID

9 September 2017

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Joma Joy

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Europe PubMed Central

PubMed publication ID

9 September 2017

author name string

Jin Xu

1

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

Anqi Chen

2

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

Vanessa Joanne Xavier

4

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

Esther H Q Ong

5

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

Jeffrey Hill

6

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Europe PubMed Central

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9 September 2017

Christina L L Chai

7

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Europe PubMed Central

PubMed publication ID

9 September 2017

publication date

8 August 2013

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Europe PubMed Central

PubMed publication ID

9 September 2017

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Europe PubMed Central

PubMed publication ID

9 September 2017

8

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Europe PubMed Central

PubMed publication ID

9 September 2017

9

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Europe PubMed Central

PubMed publication ID

9 September 2017

1483-1494

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

Covalent modifiers: an orthogonal approach to drug design

1 reference

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The resurgence of covalent drugs

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Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

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Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases

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A structure-guided approach to creating covalent FGFR inhibitors

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Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the hum

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21 January 2018

Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine

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21 January 2018

Structural bioinformatics-based design of selective, irreversible kinase inhibitors

1 reference

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Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

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Reversible covalent inhibition of a protein target.

1 reference

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Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development

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Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.

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Mnk earmarks eIF4E for cancer therapy

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Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

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Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

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21 January 2018

Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides.

1 reference

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21 January 2018

Divergent syntheses of resorcylic acid lactones: L-783277, LL-Z1640-2, and hypothemycin

1 reference

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21 January 2018

A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase

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21 January 2018

Molecular modeling and crystal structure of ERK2-hypothemycin complexes

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21 January 2018

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

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21 January 2018

Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process

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21 January 2018

Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli.

1 reference

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21 January 2018

Chemistry and biology of resorcylic acid lactones

1 reference

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21 January 2018

Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III.

1 reference

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21 January 2018

E6201 [(3S,4R,5Z,8S,9S,11E)-14-(ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (M

1 reference

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21 January 2018

In vivo efficacy of natural product-inspired irreversible kinase inhibitors

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21 January 2018

Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors.

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21 January 2018

Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.

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21 January 2018

Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site

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21 January 2018

Synthesis of a resorcylic acid lactone (RAL) library using fluorous-mixture synthesis and profile of its selectivity against a panel of kinases

1 reference

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21 January 2018

Molecular editing of kinase-targeting resorcylic acid lactones (RAL): Fluoroenone RAL.

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21 January 2018

A novel palladium-catalyzed hydroalkoxylation of alkenes with a migration of double bond.

1 reference

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21 January 2018

Access to Resorcylic Acid Lactones via Phosphonate Based Intramolecular Olefination

1 reference

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21 January 2018

An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery?

1 reference

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21 January 2018

Kinase inhibition by deoxy analogues of the resorcylic lactone L-783277.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300231

21 January 2018

Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300231

21 January 2018

Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships

1 reference

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21 January 2018

Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK

1 reference

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7 January 2021

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10.1002/CMDC.201300231

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

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