(Q39115423)

9 September 2017

title

Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells (English)

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9 September 2017

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Ali H Zaidi

1

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9 September 2017

Yoshihiro Komatsu

2

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9 September 2017

Lori A Kelly

3

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9 September 2017

Usha Malhotra

4

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9 September 2017

Christina Rotoloni

5

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9 September 2017

Juliann E Kosovec

6

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9 September 2017

Haris Zahoor

7

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9 September 2017

Rory Makielski

8

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9 September 2017

Astha Bhatt

9

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9 September 2017

Toshitaka Hoppo

10

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9 September 2017

Blair A Jobe

11

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9 September 2017

publication date

1 August 2013

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9 September 2017

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9 September 2017

volume

31

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9 September 2017

issue

7

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9 September 2017

page(s)

480-489

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Hedgehog signaling in animal development: paradigms and principles

9 September 2017

cites work

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https://api.crossref.org/works/10.3109%2F07357907.2013.820317

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Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma.

21 January 2018

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Epidermal growth factor receptor and hedgehog signaling pathways are active in esophageal cancer cells from rat reflux model

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Hedgehog signaling drives cellular survival in human colon carcinoma cells

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Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis

21 January 2018

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Medulloblastoma growth inhibition by hedgehog pathway blockade

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Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926

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Targeting Hedgehog--a cancer stem cell pathway

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HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

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Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

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Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

21 January 2018

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Drugging the Cancer Stem Cell Compartment: Lessons Learned from the Hedgehog and Wnt Signal Transduction Pathways

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Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms

21 January 2018

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Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal

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Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics

21 January 2018

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Control of stem cells and cancer stem cells by Hedgehog signaling: pharmacologic clues from pathway dissection

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Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

21 January 2018

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Pharmacokinetics of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors: the role of alpha-1-acid glycoprotein binding

21 January 2018

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Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome

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Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

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Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells

21 January 2018

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Prevention of Barrett esophagus and esophageal adenocarcinoma by smoothened inhibitor in a rat model of gastroesophageal reflux disease

21 January 2018

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Cancers with increasing incidence trends in the United States: 1999 through 2008.

21 January 2018

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Combined-modality therapy for esophageal and gastroesophageal junction cancers

21 January 2018

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A comparison of primary oesophageal squamous epithelial cells with HET-1A in organotypic culture.

21 January 2018

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Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation

21 January 2018

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Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357907.2013.820317

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357907.2013.820317

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357907.2013.820317

Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357907.2013.820317

Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357907.2013.820317

10.3109/07357907.2013.820317

21 January 2018

Identifiers

DOI

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9 September 2017

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