Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q33925257)
Watch
English
Targeting Hedgehog--a cancer stem cell pathway
scientific article
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
2888641
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20530699%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
review article
1 reference
stated in
Europe PubMed Central
title
Targeting Hedgehog--a cancer stem cell pathway
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2888641
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20530699%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
main subject
neoplastic stem cells
1 reference
based on heuristic
inferred from title
author
William Matsui
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
2888641
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20530699%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
author name string
Akil A Merchant
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
2888641
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20530699%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
language of work or name
English
0 references
publication date
8 June 2010
1 reference
stated in
Europe PubMed Central
PMC publication ID
2888641
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20530699%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
published in
Clinical Cancer Research
1 reference
stated in
Europe PubMed Central
PMC publication ID
2888641
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20530699%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
volume
16
1 reference
stated in
Europe PubMed Central
PMC publication ID
2888641
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20530699%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
issue
12
1 reference
stated in
Europe PubMed Central
PMC publication ID
2888641
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20530699%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
page(s)
3130-3140
1 reference
stated in
Europe PubMed Central
PMC publication ID
2888641
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20530699%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
cites work
Cancer stem cells and self-renewal.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
The difficulty of targeting cancer stem cell niches
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Targeting Wnt signaling: can we safely eradicate cancer stem cells?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Targeting Notch to target cancer stem cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
GDC-0449-a potent inhibitor of the hedgehog pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Dual and opposing roles of primary cilia in medulloblastoma development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Paracrine Hedgehog signaling in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Development of mammary tumors by conditional expression of GLI1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
A small molecule that binds Hedgehog and blocks its signaling in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Role of hedgehog signaling in ovarian cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog: functions and mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
A paracrine requirement for hedgehog signalling in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
The epithelial-mesenchymal transition generates cells with properties of stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
The EWS/FLI1 oncogenic transcription factor deregulates GLI1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
The Gli code: an information nexus regulating cell fate, stemness and cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Patched1 regulates hedgehog signaling at the primary cilium
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Essential role of stromally induced hedgehog signaling in B-cell malignancies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Identification of pancreatic cancer stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog signaling promotes medulloblastoma survival via Bc/II
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog/Ras interactions regulate early stages of pancreatic cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
The paradox of response and survival in cancer therapeutics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Vertebrate Smoothened functions at the primary cilium
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Tissue repair and stem cell renewal in carcinogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog signalling in cancer formation and maintenance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog signalling in the mouse requires intraflagellar transport proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Small molecule modulation of Smoothened activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Mutations in SUFU predispose to medulloblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Hedgehog signaling in animal development: paradigms and principles
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Activating Smoothened mutations in sporadic basal-cell carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Mutations affecting segment number and polarity in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
5 July 2018
Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
29 October 2018
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
29 October 2018
Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
29 October 2018
Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
29 October 2018
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
29 October 2018
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
29 October 2018
Medulloblastoma growth inhibition by hedgehog pathway blockade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
29 October 2018
Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
29 October 2018
Teratogen-mediated inhibition of target tissue response to Shh signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888641
retrieved
29 October 2018
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20530699
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Congenital Deformities in Lambs, Calves, and Goats Resulting from Maternal Ingestion ofVeratrum californicum; Hare Lip, Cleft Palate, Ataxia, and Hypoplasia of Metacarpal and Metatarsal Bones
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20530699
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1158/1078-0432.CCR-09-2846
1 reference
stated in
Europe PubMed Central
PMC publication ID
2888641
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20530699%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
PMC publication ID
2888641
1 reference
stated in
Europe PubMed Central
PMC publication ID
2888641
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20530699%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
PubMed publication ID
20530699
1 reference
stated in
Europe PubMed Central
PMC publication ID
2888641
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20530699%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
ResearchGate publication ID
44656427
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit
