(Q40034798)

16 September 2017

The EWS/FLI1 oncogenic transcription factor deregulates GLI1. (English)

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16 September 2017

J P Zwerner

1

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16 September 2017

J Joo

2

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16 September 2017

K L Warner

3

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16 September 2017

L Christensen

4

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16 September 2017

S Hu-Lieskovan

5

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16 September 2017

T J Triche

6

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16 September 2017

W A May

7

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16 September 2017

language of work or name

English

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publication date

17 December 2007

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16 September 2017

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16 September 2017

27

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16 September 2017

3282-3291

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16 September 2017

23

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210991

16 September 2017

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cites work

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Prostate carcinoma and stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Biology of EWS/ETS fusions in Ewing's family tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Dual degradation signals control Gli protein stability and tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

EWS-ETS oncoproteins: the linchpins of Ewing tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

GLI transcription factors: mediators of oncogenic Hedgehog signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

No evidence for mutations or altered expression of the Suppressor of Fused gene (SUFU) in primitive neuroectodermal tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Mutations in SUFU predispose to medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

A role of PDGFRalpha in basal cell carcinoma proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

The treatment of localized Ewing's sarcoma: the experience at the Istituto Ortopedico Rizzoli in 163 cases treated with and without adjuvant chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

inferred from DOI database lookup

7 January 2021

based on heuristic

Ewing's sarcoma.Case against surgery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210991

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1210991

1 reference

Dimensions Publication ID

16 September 2017

0 references

1 reference