(Q39141019)

22 February 2018

title

The integrated stress response and proteotoxicity in cancer therapy (English)

1 reference

22 February 2018

author name string

David J McConkey

series ordinal

1

1 reference

22 February 2018

language of work or name

English

0 references

publication date

1 January 2017

1 reference

22 February 2018

Biochemical and Biophysical Research Communications

number of pages

4

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

22 February 2018

volume

482

1 reference

22 February 2018

issue

3

1 reference

22 February 2018

page(s)

450-453

1 reference

22 February 2018

The Mitochondrial Basis of Aging

cites work

1 reference

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17 June 2018

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

17 June 2018

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17 June 2018

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Inhibition of inducible heat shock protein-70 (hsp72) enhances bortezomib-induced cell death in human bladder cancer cells

17 June 2018

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CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

17 June 2018

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HDAC inhibitor modulation of proteotoxicity as a therapeutic approach in cancer

17 June 2018

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17 June 2018

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Non-canonical inflammasome activation targets caspase-11

17 June 2018

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In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells

17 June 2018

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Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

17 June 2018

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Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

17 June 2018

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17 June 2018

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Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.

17 June 2018

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17 June 2018

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NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells

17 June 2018

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17 June 2018

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17 June 2018

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

17 June 2018

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Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

17 June 2018

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Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis

17 June 2018

1 reference

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Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

17 June 2018

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

17 June 2018

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PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Heat-shock cognate 70 is required for the activation of heat-shock factor 1 in mammalian cells

17 June 2018

1 reference

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Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein

17 June 2018

1 reference

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Function and regulation of cullin-RING ubiquitin ligases

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors

17 June 2018

1 reference

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Protein degradation and protection against misfolded or damaged proteins

17 June 2018

1 reference

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Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway

17 June 2018

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Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Regulated translation initiation controls stress-induced gene expression in mammalian cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Protein degradation in mitochondria

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Perk is essential for translational regulation and cell survival during the unfolded protein response

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Molecular chaperones as HSF1-specific transcriptional repressors

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Cells in stress: transcriptional activation of heat shock genes

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Heat shock, stress proteins, chaperones, and proteotoxicity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Social controls on cell survival and cell death

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

First proteasome inhibitor approved for multiple myeloma

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319732

Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28212730

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BBRC.2016.11.047

1 reference

22 February 2018

PMCID

5319732

1 reference

22 February 2018

PubMed ID

28212730

1 reference

22 February 2018