(Q39147059)

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Cardiac glycosides correct aberrant splicing of IKBKAP-encoded mRNA in familial dysautonomia derived cells by suppressing expression of SRSF3.

scientific article published on 18 June 2013

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23711097%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Cardiac glycosides correct aberrant splicing of IKBKAP-encoded mRNA in familial dysautonomia derived cells by suppressing expression of SRSF3 (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23711097%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

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1 March 2020

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Sylvia L Anderson

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23711097%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Jinsong Qiu

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23711097%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Berish Y Rubin

4

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1 March 2020

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18 June 2013

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1 March 2020

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Europe PubMed Central

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1 March 2020

280

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1 March 2020

15

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1 March 2020

3632-3646

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1 March 2020

The molecular basis of familial dysautonomia: overview, new discoveries and implications for directed therapies

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Familial dysautonomia is caused by mutations of the IKAP gene

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

IKAP is a scaffold protein of the IkappaB kinase complex

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Purification and characterization of the human elongator complex

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Elongator function in tRNA wobble uridine modification is conserved between yeast and plants.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Tocotrienols induce IKBKAP expression: a possible therapy for familial dysautonomia

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

EGCG corrects aberrant splicing of IKAP mRNA in cells from patients with familial dysautonomia

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Rescue of a human mRNA splicing defect by the plant cytokinin kinetin

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Olfactory stem cells, a new cellular model for studying molecular mechanisms underlying familial dysautonomia

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Tocotrienols reverse IKAP and monoamine oxidase deficiencies in familial dysautonomia

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Familial dysautonomia: update and recent advances

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Can the therapeutic efficacy of tocotrienols in neurodegenerative familial dysautonomia patients be measured clinically?

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Nutraceutical-mediated restoration of wild-type levels of IKBKAP-encoded IKAP protein in familial dysautonomia-derived cells.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Old drugs--new uses

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

New uses for old drugs

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

ASD: a bioinformatics resource on alternative splicing

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

A humanized IKBKAP transgenic mouse models a tissue-specific human splicing defect

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Regulation of alternative splicing: more than just the ABCs

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Differential recruitment of pre-mRNA splicing factors to alternatively spliced transcripts in vivo

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

The CD44 alternative v9 exon contains a splicing enhancer responsive to the SR proteins 9G8, ASF/SF2, and SRp20.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Role of SFRS13A in low-density lipoprotein receptor splicing

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Modulating alternative splicing by cotranscriptional cleavage of nascent intronic RNA.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Loss of exon identity is a common mechanism of human inherited disease

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Alternative splicing and tumor progression

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Splice variants as cancer biomarkers

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

The emerging role of splicing factors in cancer

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Cardiac glycosides as novel cancer therapeutic agents

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Nucleolus and c-Myc: potential targets of cardenolide-mediated antitumor activity

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Molecular mechanisms of Na/K-ATPase-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Cardiac glycoside inhibits IL-8-induced biological responses by downregulating IL-8 receptors through altering membrane fluidity

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Digitoxin-induced cytotoxicity in cancer cells is mediated through distinct kinase and interferon signaling networks

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Purification and characterization of a human tumor necrosis factor from the LuKII cell line

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

Elongator, a Multisubunit Component of a Novel RNA Polymerase II Holoenzyme for Transcriptional Elongation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12355

21 January 2018

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