(Q39173452)

9 September 2017

title

RUNX3 inhibits hypoxia-inducible factor-1α protein stability by interacting with prolyl hydroxylases in gastric cancer cells (English)

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9 September 2017

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S H Lee

1

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9 September 2017

S C Bae

series ordinal

2

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9 September 2017

K W Kim

series ordinal

3

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9 September 2017

Y M Lee

series ordinal

4

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9 September 2017

language of work or name

English

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publication date

1 April 2013

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9 September 2017

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9 September 2017

volume

33

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9 September 2017

issue

11

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9 September 2017

page(s)

1458-1467

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Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells

9 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Angiogenesis in ischemic and neoplastic disorders

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Hypoxia--a key regulatory factor in tumour growth

21 January 2018

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What Is the Evidence That Tumors Are Angiogenesis Dependent?

21 January 2018

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Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Causal relationship between the loss of RUNX3 expression and gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

RUNX3 is multifunctional in carcinogenesis of multiple solid tumors

21 January 2018

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RUNX: a trilogy of cancer genes.

21 January 2018

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RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes

21 January 2018

1 reference

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RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway

21 January 2018

1 reference

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Attenuation of green fluorescent protein half-life in mammalian cells

21 January 2018

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Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

21 January 2018

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HIF-1: using two hands to flip the angiogenic switch

21 January 2018

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

21 January 2018

1 reference

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Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

21 January 2018

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Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

21 January 2018

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Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis

21 January 2018

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From vessel sprouting to normalization: role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery.

21 January 2018

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Targeting HIF-1 for cancer therapy

21 January 2018

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Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Targeting the hypoxia-inducible factor (HIF) pathway in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

1'-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Pim-1 kinase phosphorylates and stabilizes RUNX3 and alters its subcellular localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Jab1/CSN5 induces the cytoplasmic localization and degradation of RUNX3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

HDAC2 promotes cell migration/invasion abilities through HIF-1α stabilization in human oral squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Targeting tumor angiogenesis with histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Tid-1 interacts with the von Hippel-Lindau protein and modulates angiogenesis by destabilization of HIF-1alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

Frequent loss of RUNX3 gene expression in remnant stomach cancer and adjacent mucosa with special reference to topography.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.76

31 March 2020

Identifiers

DOI

10.1038/ONC.2013.76

1 reference

9 September 2017

1 reference