(Q39185473)

9 September 2017

title

Development of anticancer agents targeting the Hedgehog signaling (English)

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9 September 2017

Xiangqian Zhang

1

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9 September 2017

Ye Tian

series ordinal

2

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9 September 2017

Yanling Yang

series ordinal

3

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9 September 2017

Jijun Hao

series ordinal

4

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9 September 2017

publication date

17 March 2017

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Cellular and Molecular Life Sciences

9 September 2017

published in

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9 September 2017

volume

74

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9 September 2017

issue

15

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9 September 2017

page(s)

2773-2782

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https://scigraph.springernature.com/pub.10.1007/s00018-017-2497-x

9 September 2017

exact match

0 references

cites work

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Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths

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The hedgehog pathway in triple-negative breast cancer

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Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

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Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

21 January 2018

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Targeting Hedgehog--a cancer stem cell pathway

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HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

21 January 2018

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Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

21 January 2018

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Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Identification of an amplified, highly expressed gene in a human glioma

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Novel mutations in the PATCHED gene in basal cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Activating Smoothened mutations in sporadic basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Patched-one or smoothened gene mutations are infrequent in chondrosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Mutations in SUFU predispose to medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

A paracrine requirement for hedgehog signalling in cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

21 January 2018

1 reference

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Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Tumorigenesis: Testing ground for cancer stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

A restricted cell population propagates glioblastoma growth after chemotherapy

21 January 2018

1 reference

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Molecular therapy targeting Sonic hedgehog and hepatocyte growth factor signaling in a mouse model of medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Tumor-stroma interaction in orthotopic primary pancreatic cancer xenografts during hedgehog pathway inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Novel lipid modifications of secreted protein signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Teratogen-mediated inhibition of target tissue response to Shh signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Cytotoxic effects induced by docetaxel, gefitinib, and cyclopamine on side population and nonside population cell fractions from human invasive prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Cyclopamine: from cyclops lambs to cancer treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Enhancement of cyclopamine via conjugation with nonmetabolic sugars

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

A phase I study of PF-04449913, an oral hedgehog inhibitor, in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Treatment with PF-04449913, an oral smoothened antagonist, in patients with myeloid malignancies: a phase 1 safety and pharmacokinetics study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Structure of the human smoothened receptor bound to an antitumour agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Smoothened variants explain the majority of drug resistance in basal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Hedgehog signaling drives cellular survival in human colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin β4-mediated FAK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Blocking signaling at the level of GLI regulates downstream gene expression and inhibits proliferation of canine osteosarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Arsenic trioxide inhibits the Hedgehog pathway which is aberrantly activated in acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Opportunities for Trisenox (arsenic trioxide) in the treatment of myelodysplastic syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Phosphodiesterase inhibitors: new opportunities for the treatment of asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Effects of roflumilast, a phosphodiesterase-4 inhibitor, on hypoxia- and monocrotaline-induced pulmonary hypertension in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Treating brain tumors with PDE4 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Phosphodiesterase 4D inhibitors limit prostate cancer growth potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-017-2497-X

Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.

21 January 2018

1 reference

12 December 2020

3',5'-Cyclic nucleotide phosphodiesterase in tumor cells as potential target for tumor growth inhibition

1 reference

12 December 2020

Expression of hedgehog signalling components in adult mouse testis

1 reference

12 December 2020

In-patient major depression: is rolipram as effective as amitriptyline?

1 reference

12 December 2020

Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

1 reference

12 December 2020

Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations

1 reference

12 December 2020

Evolution of the hedgehog gene family.

1 reference

12 December 2020

Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity

1 reference

12 December 2020

Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors

1 reference

12 December 2020

Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002.

1 reference

12 December 2020

Apremilast (Otezla): A New Oral Treatment for Adults With Psoriasis and Psoriatic Arthritis.

1 reference

12 December 2020

Targeting the Hedgehog pathway in cancer

1 reference

12 December 2020

Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD.

1 reference

12 December 2020

10.1007/S00018-017-2497-X

Identifiers

DOI

1 reference

9 September 2017

1 reference