(Q39201929)

9 September 2017

title

Proteasome expression and activity in cancer and cancer stem cells (English)

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9 September 2017

main subject

neoplastic stem cells

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based on heuristic

inferred from title

author

Ioannis A. Voutsadakis

series ordinal

1

object named as

Ioannis A Voutsadakis

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9 September 2017

publication date

1 March 2017

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9 September 2017

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9 September 2017

volume

39

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9 September 2017

issue

3

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9 September 2017

page(s)

1010428317692248

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Strategies for homeostatic stem cell self-renewal in adult tissues

9 September 2017

cites work

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Evidence for a stem cell hierarchy in the adult human breast

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Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration

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Prospective identification of tumorigenic breast cancer cells

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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

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Colon cancer: cancer stem cells markers, drug resistance and treatment

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Biology and Clinical Relevance of Acute Myeloid Leukemia Stem Cells.

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21 January 2018

Lung cancer stem cells

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Hallmarks of Cancer: The Next Generation

21 January 2018

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The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together

21 January 2018

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The proteasome: a proteolytic nanomachine of cell regulation and waste disposal

21 January 2018

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The ubiquitin-proteasome system in colorectal cancer

21 January 2018

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Proteasomes can degrade a significant proportion of cellular proteins independent of ubiquitination

21 January 2018

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Emerging roles of immunoproteasomes beyond MHC class I antigen processing

21 January 2018

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Assembly of an Evolutionarily Conserved Alternative Proteasome Isoform in Human Cells.

21 January 2018

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Molecular mechanisms of proteasome assembly

21 January 2018

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The Cdc48-Vms1 complex maintains 26S proteasome architecture

21 January 2018

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The proteasome complex and the maintenance of pluripotency: sustain the fate by mopping up?

21 January 2018

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Gates, Channels, and Switches: Elements of the Proteasome Machine

21 January 2018

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Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis

21 January 2018

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The noncanonical NF-κB pathway

21 January 2018

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https://api.crossref.org/works/10.1177%2F1010428317692248

In vivo imaging, tracking, and targeting of cancer stem cells

21 January 2018

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https://api.crossref.org/works/10.1177%2F1010428317692248

Targeted elimination of breast cancer cells with low proteasome activity is sufficient for tumor regression

21 January 2018

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https://api.crossref.org/works/10.1177%2F1010428317692248

Identification of chemoradiation-resistant osteosarcoma stem cells using an imaging system for proteasome activity

21 January 2018

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https://api.crossref.org/works/10.1177%2F1010428317692248

Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients

21 January 2018

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https://api.crossref.org/works/10.1177%2F1010428317692248

26S proteasome activity is down-regulated in lung cancer stem-like cells propagated in vitro

21 January 2018

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https://api.crossref.org/works/10.1177%2F1010428317692248

Radioresistance of prostate cancer cells with low proteasome activity

21 January 2018

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https://api.crossref.org/works/10.1177%2F1010428317692248

Differential Effects of the Proteasome Inhibitor NPI-0052 against Glioma Cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Cancer Stem-like Properties in Colorectal Cancer Cells with Low Proteasome Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

The LMP7-K allele of the immunoproteasome exhibits reduced transcript stability and predicts high risk of colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Pluripotency transcription factors in the pathogenesis of colorectal cancer and implications for prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Identification of new hub genes associated with bladder carcinoma via bioinformatics analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Proteomic profiling identified multiple short-lived members of the central proteome as the direct targets of the addicted oncogenes in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

A putative role for the immunoproteasome in the maintenance of pluripotency in human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Transcriptional activation of human CDCA8 gene regulated by transcription factor NF-Y in embryonic stem cells and cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

The short isoform of NF-YA belongs to the embryonic stem cell transcription factor circuitry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Estrogen receptor alpha and nuclear factor Y coordinately regulate the transcription of the SUMO-conjugating UBC9 gene in MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

The CCAAT box-binding transcription factor NF-Y regulates basal expression of human proteasome genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

The RNA-binding protein Musashi-1 regulates proteasome subunit expression in breast cancer- and glioma-initiating cells

21 January 2018

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https://api.crossref.org/works/10.1177%2F1010428317692248

A role for Numb in p53 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Function of RNA-binding protein Musashi-1 in stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Epithelial-Mesenchymal Transition (EMT) and Regulation of EMT Factors by Steroid Nuclear Receptors in Breast Cancer: A Review and in Silico Investigation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Proteasome inhibition represses ERalpha gene expression in ER+ cells: a new link between proteasome activity and estrogen signaling in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Regulation of proteasome activity in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Coordinated regulation of protein synthesis and degradation by mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Nrf2 signaling in coordinated activation of antioxidant gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Drug-induced senescence generates chemoresistant stemlike cells with low reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Nrf2 is required to maintain the self-renewal of glioma stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Regulation of Nrf2-an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Dual roles of NRF2 in tumor prevention and progression: possible implications in cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Implication of heat shock factors in tumorigenesis: therapeutical potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Heat-shock factor 2 is a suppressor of prostate cancer invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

FOXO4 is necessary for neural differentiation of human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Pluripotency factors in embryonic stem cells regulate differentiation into germ layers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Resveratrol protects leukemic cells against cytotoxicity induced by proteasome inhibitors via induction of FOXO1 and p27Kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

G(alpha)12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 downregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Association of gankyrin and stemness factor expression in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

The oncoprotein p28GANK establishes a positive feedback loop in β-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Gankyrin: an intriguing name for a novel regulator of p53 and RB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

p28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Feedback regulation of proteasome gene expression and its implications in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Gankyrin gene deletion followed by proteomic analysis: insight into the roles of Gankyrin in tumorigenesis and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

NF-Y joins E2Fs, p53 and other stress transcription factors at the apoptosis table

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

SUMOylation of Psmd1 controls Adrm1 interaction with the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Regulation of proteasome complexes by gamma-interferon and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Bortezomib (VELCADE) in metastatic breast cancer: pharmacodynamics, biological effects, and prediction of clinical benefits

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

A phase II study of bortezomib in the treatment of metastatic malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Synthetic Proteins Potently and Selectively Bind the Oncoprotein Gankyrin, Modulate Its Interaction with S6 ATPase, and Suppress Gankyrin/MDM2-Dependent Ubiquitination of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

Cancer vulnerabilities unveiled by genomic loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

The Proteasome Restricts Permissive Transcription at Tissue-Specific Gene Loci in Embryonic Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1010428317692248

21 January 2018

Identifiers

DOI

10.1177/1010428317692248

1 reference

9 September 2017

1 reference