(Q39214717)

10 September 2017

title

Wnt3a regulates proliferation, apoptosis and function of pancreatic NIT-1 beta cells via activation of IRS2/PI3K signaling (English)

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10 September 2017

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Shuyan Gui

1

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10 September 2017

Gang Yuan

2

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10 September 2017

Lu Wang

3

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10 September 2017

Lili Zhou

4

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10 September 2017

Ying Xue

5

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10 September 2017

Yikai Yu

6

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10 September 2017

Jianhua Zhang

7

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10 September 2017

Muxun Zhang

8

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10 September 2017

Yan Yang

9

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10 September 2017

Dao Wen Wang

10

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10 September 2017

publication date

1 July 2013

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Journal of Cellular Biochemistry

10 September 2017

published in

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10 September 2017

volume

114

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10 September 2017

issue

7

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10 September 2017

page(s)

1488-1497

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Wnt/beta-catenin signaling

10 September 2017

cites work

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Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

21 January 2018

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Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells

21 January 2018

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Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men.

21 January 2018

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

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Prime suspect: the TCF7L2 gene and type 2 diabetes risk

21 January 2018

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Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes

21 January 2018

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Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

21 January 2018

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Axin inhibits extracellular signal-regulated kinase pathway by Ras degradation via beta-catenin.

21 January 2018

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Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?

21 January 2018

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Decreasing IRS-2 expression in pancreatic β-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression

21 January 2018

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Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation

21 January 2018

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Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

21 January 2018

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Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis

21 January 2018

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DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway

21 January 2018

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Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

21 January 2018

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Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance

21 January 2018

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Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function

21 January 2018

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Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?

21 January 2018

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Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

21 January 2018

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Molecular insights into insulin action and secretion

21 January 2018

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Wnt signaling regulates pancreatic beta cell proliferation

21 January 2018

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Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules

21 January 2018

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The INK4a/ARF network in tumour suppression

21 January 2018

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RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

21 January 2018

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Genetic control of cell size

21 January 2018

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Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.

21 January 2018

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Beta-cell adaptation and decompensation during the progression of diabetes.

21 January 2018

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Wnt signaling: relevance to beta-cell biology and diabetes

21 January 2018

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Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells

21 January 2018

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Wnt signaling regulates mitochondrial physiology and insulin sensitivity

21 January 2018

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Both ERK and Wnt/beta-catenin pathways are involved in Wnt3a-induced proliferation

21 January 2018

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Global and societal implications of the diabetes epidemic

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.24490

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10 September 2017

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